Can I Give My Dog Benadryl?

Medically Reviewed by Vanesa Farmer, DVM on December 26, 2024
4 min read

Dogs are curious and energetic, so it’s inevitable that some of them will wind up in some sticky situations. From running through some poison ivy to getting stung by a bee, there are plenty of problems that can lead to your dog feeling itchy, uncomfortable, and swollen from an allergic reaction. 

Your dog doesn’t need to suffer, though. With a vet’s guidance, you can use diphenhydramine (Benadryl) to ease the worst of their allergy symptoms. Benadryl is an antihistamine that helps relieve the symptoms of allergies in both humans and animals. It can also be used to relieve the symptoms of motion sickness if a dog needs to be transported long distances. 

Here’s how Benadryl can be given to dogs safely. 

Getting the dosage right is important because most Benadryl tablets are intended for humans. Dogs are smaller than people, so they need less Benadryl than a person. Dogs also metabolize Benadryl differently, so it’s not a good idea to rely on human dosing guidelines. Always consult your veterinarian before giving Benadryl to your dog.

The correct dosage of diphenhydramine for dogs depends on their weight. A small dog will need much less than a big dog to receive the same positive effects. According to the Merck Veterinary Manual, the safe dosage is 2-4 milligrams of medication per kilogram of weight, or 0.9 to 1.8 milligrams per pound. This amount can be given two to three times daily, depending on your dog’s symptoms. 

Benadryl is not approved by the FDA for use in animals. So there are no Benadryl formulations specifically for pets. The human medication is used “off-label.” If you are going to give your dog Benadryl, keep this guidance in mind: 

  • Never offer your dog medications with decongestants or alcohol in the formula. Only offer them medications with diphenhydramine and no other active ingredients. Decongestants and alcohol can be toxic for your dog. 
  • Dogs should never be given time-released drug capsules. Your dog’s stomach works differently from yours, and a capsule that works well for humans may overdose your dog. Plus, if they bite the capsule, they may get the entire dose at once instead of it being spread out over time. 
  • For small dogs, it may be better to use children’s Benadryl than Benadryl for adults. This lets you adjust the dose more carefully. 
  • If you are going to use liquid Benadryl medication instead of tablets, talk to your dog’s vet to make sure you use the right dosage. Liquid medication is absorbed differently, and the 2-4 milligrams per kilogram guideline may not apply. 

Dogs may have the following side effects after being given Benadryl:

  • Sleepiness
  • Dry mouth
  • Difficulty peeing
  • Rapid breathing
  • Salivating more than normal
  • Increased heart rate

These side effects are less common:

  • Nausea and vomiting
  • Increased or decreased appetite

While the right dose of Benadryl is safe for most dogs, occasionally a dog may be allergic to the medication itself. Signs of a Benadryl allergy include:

Benadryl overdose 

Symptoms of a Benadryl overdose in dogs range from seizures to respiratory failure to a coma, depending on the size of the overdose. If you believe your dog has overdosed on Benadryl, contact your vet immediately and follow their instructions for emergency treatment.

If your dog reacts poorly to Benadryl but needs regular allergy treatment for a seasonal allergy, there are some alternatives you can use. Both cetirizine (Zyrtec) and loratadine (Claritin) are considered safe for dogs in the right dosages. However, they are also frequently combined with other ingredients like decongestants, which can hurt your dog. Always consult with a vet before giving your dog any new medication. 

Call the vet immediately if your dog is: 

  • Having seizures
  • Vomiting
  • Having diarrhea
  • Showing signs of swelling
  • Having trouble breathing

These may be signs of a serious allergic response or overdose that needs immediate treatment.  

Benadryl can help relieve allergy symptoms in dogs, but always consult your vet first. Use only plain diphenhydramine and avoid formulas with decongestants or alcohol. The correct dosage depends on your dog's weight. Monitor for side effects, and contact your vet immediately if you notice any serious issues. If Benadryl isn't suitable, discuss alternatives with your veterinarian.