What Is Nattokinase?
Nattokinase is a natural enzyme. It comes from natto, a Japanese dish made from soybeans fermented with a bacterium (Bacillus subtilis). Nattokinase can also be taken as a supplement.
Nattokinase Benefits
Nattokinase may have some benefits, such as preventing blood clots, but very few studies have looked into it. More research is needed to understand its benefits and risks.
Nattokinase and heart health
There's some early evidence that nattokinase may have benefits for heart and artery health. For example, it can help prevent arteries from becoming narrower over time. It may also help lower blood pressure and cholesterol. Finally, people who eat a lot of natto may be less likely to die of heart disease.
Nattokinase and blood clots
One study shows that a nattokinase supplement lowers the risk of blood clots after long plane flights. It may also help prevent deep vein thrombosis — a type of blood clot that usually forms in the leg. This is because nattokinase breaks down fibrin, the part of blood involved in clotting.
Nattokinase and blood pressure
Other early studies show that nattokinase may help lower blood pressure. However, we need more research to confirm that it's effective.
Nattokinase and Alzheimer’s
Some studies suggest that nattokinase can break down amyloid plaques, which are abnormal clumps of protein in the brain. These plaques play a role in Alzheimer’s disease. Furthermore, heart and brain health are closely linked. By boosting heart health, nattokinase may also protect the brain.
Nattokinase dosage
There’s no set dosage for nattokinase. Quality and active ingredients in supplements may vary widely from maker to maker. This makes it very hard to set a standard dose. Ask your doctor for advice.
Nattokinase in Food
Researchers first found nattokinase in the Japanese food natto, made with fermented soybeans. It doesn’t come from the soybeans themselves; instead, nattokinase is made during the fermentation process. The soybeans are soaked, cooked, and blended with a Bacillus subtilis for fermenting for up to a day, then the natto ages as it's cooled and refrigerated for up to a week to achieve its sticky texture.
You can't get nattokinase from other soy foods.
Nattokinase supplements
If you don’t like fermented soybeans, you can take nattokinase as a supplement. The supplement is generally used to prevent blood clots and improve circulation. One study showed that nattokinase supplements can lower blood pressure. But other results are mixed. All in all, more research is needed to learn about the effects of nattokinase.
Don’t start any new supplement without talking to your doctor. Nattokinase and other supplements can interact with other medications you take or cause side effects. Your doctor can help you figure out which supplements are right for you and how much to take.
Nattokinase Dangers
Tell your doctor about any supplements you're taking, even if they're natural. That way, your doctor can check for any potential side effects or interactions with medications.
Nattokinase side effects
Nattokinase is safe when taken as food. More studies are needed to see if nattokinase taken as a supplement is safe for repeated or long-term use.
Nattokinase risks
If you have any blood clotting disorders, don't take nattokinase supplements unless a doctor says it's safe. Even though nattokinase may help prevent clots, there’s also a chance that taking it can cause a clot to suddenly dislodge, leading to a stroke. You may need to stop taking nattokinase if you're planning to have surgery.
Given the lack of evidence about its safety, doctors don't recommend nattokinase for children or for women who are pregnant or breastfeeding.
If you’re allergic to natto (fermented soybeans), nattokinase could cause an allergic reaction.
Nattokinase interactions
If you take any medications regularly, talk to your doctor before you start using nattokinase supplements. The supplements could interact with blood thinners and other drugs that reduce clotting, such as aspirin and ibuprofen. They could cause excess bleeding and bruising.
The FDA does regulate dietary supplements, but under a different set of regulations than those for foods and drugs. It is up to the manufacturers to ensure the safety and correct labeling of supplements.
Takeaways
Nattokinase is a natural enzyme found in fermented soybeans (natto). It may help prevent blood clots and lower blood pressure, but more research is needed to be sure. You can buy nattokinase supplements, but talk to your doctor first to see if they are right for you.
Nattokinase FAQs
What is nattokinase used for?
Nattokinase is used to prevent blood clots.
Who should not take nattokinase?
You should not take nattokinase if you take aspirin or other blood thinners or have a blood clotting (coagulation) disorder.
Is nattokinase vitamin K2?
Raw natto (fermented soybeans) is high in vitamin K. But nattokinase is not vitamin K2.