LIVER EXTRACT: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Liver extract is a product that comes from animal liver, most commonly from cattle. Liver extract is used to make medicine.

People take liver extract by mouth or by injection for various conditions, especially for liver health or as a source of iron and vitamin B12, but there is no good scientific evidence to support these uses.

How does it work ?

Liver extract contains vitamin B12, folic acid, and iron. In animals, it seems to increase the number of liver cells. It is not known how liver extract might work for medicinal uses in people.

Uses & Effectiveness

Possibly Ineffective for

Chronic fatigue syndrome (CFS). Some research suggests that injecting a combination of bovine liver extract, folic acid, and vitamin B12 for 3 weeks does not seem to improve fatigue in people with CFS.

Insufficient Evidence for

Swelling (inflammation) of the liver caused by the hepatitis C virus (hepatitis C). Early research suggests that injecting liver extract plus flavin adenine dinucleotide intravenously (by IV) or as a shot into the muscle might improve response to interferon-alpha or interferon-beta therapy in people with hepatitis C.
Improving liver function.
Preventing liver damage.
Treating liver diseases.
Treating allergies.
Improving muscle development.
Improving strength and physical endurance.
Removing chemicals from the body (detoxification).
Recovery from chemical addiction.
Other conditions.

More evidence is needed to rate the effectiveness of liver extract for these uses.

Side Effects

When taken by mouth: There isn't enough information to know if liver extract is safe. Since some preparations of liver extract come from animals, there is concern about possible contamination from diseased animals. However, so far there are no reports of diseases in humans that were caused by ingestion of contaminated liver.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if liver extract is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Too much iron in the body, including a condition called hemochromatosis: Liver extract contains iron and might make iron metabolism disorders worse. If you have one of these disorders, don't use liver extract.

Interactions

We currently have no information for LIVER EXTRACT overview.

Dosing

The appropriate dose of liver extract depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for liver extract. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

Castellani, A., Colafelice, M., and Fichera, M. [Hepatoprotective effect of a combination of UDPG, vitamin B 12 and liver extract in psychiatric patients with liver diseases]. Clin.Ter. 9-30-1978;86(6):567-576. View abstract.

Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterology 2004;51(58):1109-1114. View abstract.

Fukuda Y, Sawata M, Washizuka M, et al. [Effect of liver hydrolysate on hepatic proliferation in regenerating rat liver]. Nippon Yakurigaku Zasshi 1999;114:233-8.

Fukuda, Y., Sawata, M., Washizuka, M., Higashino, R., Fukuta, Y., Tanaka, Y., and Takei, M. [Effect of liver hydrolysate on hepatic proliferation in regenerating rat liver]. Nippon Yakurigaku Zasshi 1999;114(4):233-238. View abstract.

Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. View abstract.

Kondoh, K., Imaide, Y., Uchida, M., and Watanabe, H. [Effect of the administration of liver extract after surgical operations in urology]. Hinyokika Kiyo 1986;32(1):163-167. View abstract.

Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

Murray MT. Encyclopedia of Nutritional Supplements. Rocklin, CA: Prima Health, 1996.

Pallotti, S., Paolucci, D., and Isidori, A. Hepatic activity in the generation of somatomedins: effects of administration of a liver extract. Int.J.Clin.Pharmacol.Biopharm. 1978;16(8):351-356. View abstract.

Pallotti, S., Paolucci, D., Santoro, S., and Rotolo, A. [Metabolism of somatotropin in severe liver diseases. Influence of the therapeutic administration of a liver extract]. Minerva Med. 11-14-1978;69(55):3779-3783. View abstract.

Preziosi, P., Nistico, G., and Marano, V. Double-blind study of a total liver extract in patients with hepatic dysfunction. Int.J.Clin.Pharmacol.Biopharm. 1975;11(3):210-215. View abstract.

Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. Keio J.Med. 1996;45(1):48-53. View abstract.

Yamada K, Ueda K, Shirakawa H, et al. The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats. Biol Pharm Bull 2020;43(3):554-7. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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