RABDOSIA RUBESCENS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Rabdosia rubescens is an herb. The whole plant is used to make medicine.

People use Rabdosia rubescens for a mild form of gum disease (gingivitis), an enlarged prostate (benign prostatic hyperplasia, BPH), cancer, and other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Developing research suggests chemicals in Rabdosia rubescens might harm cancer cells and might also keep them from multiplying.

Uses & Effectiveness

Insufficient Evidence for

A mild form of gum disease (gingivitis). Early research shows that taking Rabdosia rubescens might reduce symptoms of gingivitis, such as red and bleeding gums.
Cancer, including prostate cancer.
Enlarged prostate (benign prostatic hyperplasia, BPH).
Swelling (inflammation).
Other conditions.

More evidence is needed to rate the effectiveness of Rabdosia rubescens for these uses.

Side Effects

When taken by mouth: There isn't enough reliable information to know if Rabdosia rubescens is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: There isn't enough reliable information to know if Rabdosia rubescens is safe or what the side effects might be.

Pregnancy and breast-feeding: There isn't enough reliable information to know if Rabdosia rubescens is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RABDOSIA RUBESCENS
Some medications are changed and broken down by the liver. Rabdosia rubescens might increase how quickly the liver breaks down some medications. Taking Rabdosia rubescens along with some medications that are changed by the liver might decrease the effects of these medications. Before taking Rabdosia rubescens, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications moved by pumps in cells (P-glycoprotein substrates) interacts with RABDOSIA RUBESCENS
Some medications are moved by pumps in cells. Rabdosia rubescens might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications.
Some medications that are moved by these pumps include doxorubicin, etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Minor Interaction

Be watchful with this combination

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with RABDOSIA RUBESCENS
Some medications are changed and broken down by the liver. Rabdosia rubescens might increase how quickly the liver breaks down some medications. Taking Rabdosia rubescens along with some medications that are changed by the liver may decrease the effects of these medications. Before taking Rabdosia rubescens talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene), amitriptyline (Elavil), warfarin (Coumadin), glipizide (Glucotrol), losartan (Cozaar), and others.

Dosing

The appropriate dose of Rabdosia rubescens depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Rabdosia rubescens. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

Bi E, Liu D, Li Y, Mao X, Wang A, Wang J. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Braz J Med Biol Res. 2018;51(12):e7599. View abstract.

Bohanon FJ, Wang X, Ding C, et al. Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. J Surg Res. 2014;190(1):55-63. View abstract.

Chen S, Liu J, Zhang H. Efficacy of rabdosia rubescens in the treatment of gingivitis. J Huazhong Univ Sci Technolog Med Sci. 2009;29(5):659-63. View abstract.

Ikezoe T, Yang Y, Bandobashi, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther 2005;4:578-86. View abstract.

Jia T, Cai M, Ma X, Li M, Qiao J, Chen T. Oridonin inhibits IL-1ß-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-?. Int Immunopharmacol. 2019;69:382-388. View abstract.

Li F, Fan J, Wu Z, et al. Reversal effects of Rabdosia rubescens extract on multidrug resistance of MCF-7/Adr cells in vitro. Pharm Biol. 2013;51(9):1196-203. View abstract.

Liu JJ, Huang RW, Lin DJ, et al. Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. J Int Med Res 2004;32:617-25. View abstract.

Ma YC, Ke Y, Zi X, Zhao W, Shi XJ, Liu HM. Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets. 2013;13(6):611-24. View abstract.

Meade-Tollin LC, Wijeratne EM, Cooper D, et al. Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES. J Nat Prod 2004;67:2-4. View abstract.

Tian L, Xie K, Sheng D, Wan X, Zhu G. Antiangiogenic effects of oridonin. BMC Complement Altern Med. 2017;17(1):192. View abstract.

Wang S, Zhong Z, Wan J, et al. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med. 2013;41(1):177-96. View abstract.

Zhang YW, Zheng XW, Liu YJ, et al. Effect of oridonin on cytochrome P450 expression and activities in HepaRG Cell. Pharmacology. 2018;101(5-6):246-254.View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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