SWEET CLOVER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Sweet clover (Melilotus officinalis) is a plant native to Europe and now found throughout the world. Its flowering branch and leaf are used as medicine.

Sweet clover contains ingredients that might thin the blood and help wounds heal.

People use sweet clover for varicose veins, poor blood circulation, nerve pain in people with diabetes, bruises, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse sweet clover with red clover. These are not the same.

Uses & Effectiveness

We currently have no information for SWEET CLOVER overview.

Side Effects

When taken by mouth: Sweet clover is possibly safe when used appropriately. But it is possibly unsafe when used in large amounts due to the risk for liver damage and bleeding problems.

Special Precautions and Warnings

When taken by mouth: Sweet clover is possibly safe when used appropriately. But it is possibly unsafe when used in large amounts due to the risk for liver damage and bleeding problems.

Pregnancy and breast-feeding: There isn't enough reliable information to know if sweet clover is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Liver disease: Sweet clover might make liver disease worse. If you have liver problems, speak with your healthcare provider before using sweet clover.

Surgery: Sweet clover might slow blood clotting. This might increase the risk of bleeding during or after surgery. Stop using sweet clover at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications that can harm the liver (Hepatotoxic drugs) interacts with SWEET CLOVER
Sweet clover might harm the liver. Some medications can also harm the liver. Taking sweet clover along with a medication that can harm the liver might increase the risk of liver damage.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with SWEET CLOVER
Sweet clover might slow blood clotting. Taking sweet clover along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Dosing

There isn't enough reliable information to know what an appropriate dose of sweet clover might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Stojicevic, M., Dordevic, O., Kostic, L., Madanovic, N., and Karanovic, D. [Action of clove oil, eugenol, and zinc-oxide eugenol paste on the dental pulp within "in vitro" conditions]. Stomatol.Glas.Srb. 1980;27(2):85-89. View abstract.

Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., and Apiwathnasorn, C. Comparative repellency of 38 essential oils against mosquito bites. Phytother Res 2005;19(4):303-309. View abstract.

Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., Krisadaphong, P., and Apiwathnasorn, C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. Southeast Asian J Trop.Med Public Health 2004;35(2):325-333. View abstract.

Xing, F., Tan, Y., Yan, G. J., Zhang, J. J., Shi, Z. H., Tan, S. Z., Feng, N. P., and Liu, C. H. Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites. J Ethnopharmacol. 1-31-2012;139(2):343-349. View abstract.

Yang, B. H., Piao, Z. G., Kim, Y. B., Lee, C. H., Lee, J. K., Park, K., Kim, J. S., and Oh, S. B. Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent.Res. 2003;82(10):781-785. View abstract.

Yarnell E and Abascal K. Botanical medicines for headache. Alternative & Complementary Therapies (England) 2007;13:148-152.

Bakhshayeshi S, Madani SP, Hemmatabadi M, et al. Effects of Semelil (ANGIPARS) on diabetic peripheral neuropathy: a randomized, double-blind placebo-controlled clinical trial. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011;19(1):65.

Consorti G, Monarchi G, Paglianiti M, Betti E, Balercia P. Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients. J Clin Med 2024;13(4):922. View abstract.

Cornara L, Xiao J, Burlando B. Therapeutic potential of temperate forage legumes: a review. Crit Rev Food Sci Nutr 2016;56 Suppl 1:S149-61. View abstract.

Hassani M, Soleimani M, Esmaeilzadeh E, Zare-Abdollahi D, Khorram Khorshid HR. Healing Influence of Melilotus Officinalis Herbal Extract on Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice. Iran J Pharm Res 2020;19(4):321-329. View abstract.

Hogan RP III. Hemorrhagic diathesis caused by drinking an herbal tea. JAMA 1983;249:2679-80.

Paun G, Neagu E, Albu C, Savin S, Radu GL. In Vitro Evaluation of Antidiabetic and Anti-Inflammatory Activities of Polyphenolic-Rich Extracts from Anchusa officinalis and Melilotus officinalis. ACS Omega 2020;5(22):13014-13022. View abstract.

Tamura S, Warabi Y, Matsubara S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot (sweet clover) supplement. J Clin Pharm Ther 2012;37(6):724-5. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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SWEET CLOVER - Uses, Side Effects, and More