SACCHAROMYCES BOULARDII: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Saccharomyces boulardii (S. boulardii) is a type of probiotic ("friendly" organism). It's a yeast that is actually a strain of Saccharomyces cerevisiae.

"Friendly" organisms such as S. boulardii can help fight off "bad" organisms that might cause diseases. S. boulardii is different from other strains of S. cerevisiae, commonly known as brewer's yeast and baker's yeast.

People commonly use S. boulardii for treating and preventing diarrhea, including rotaviral diarrhea in children. It's also used for other types of diarrhea, acne, a digestive tract infection that can lead to ulcers, and many other conditions, but there is no good scientific evidence to support many of its other uses. There is also no good evidence to support using S. boulardii for COVID-19.

Don't confuse S. boulardii with other probiotics, or with fermented food products such as fermented milk, kefir, or yogurt. These are not the same.

Uses & Effectiveness

Likely Effective for

Diarrhea. Taking S. boulardii by mouth can reduce how long diarrhea lasts in children. It's not clear if it helps children with longer-lasting diarrhea or if it helps adults.

Possibly Effective for

Diarrhea in people taking antibiotics (antibiotic-associated diarrhea). Taking S. boulardii by mouth can help prevent diarrhea in adults and children being treated with antibiotics.
Infection of the gastrointestinal tract by bacteria called Clostridioides difficile. Taking S. boulardii by mouth seems to help prevent diarrhea from C. difficile infection. Taking it along with antibiotics also seems to help prevent this infection from coming back.
A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Taking S. boulardii by mouth along with standard H. pylori treatment helps prevent side effects such as diarrhea and nausea that occur with standard H. pylori treatment. But it isn't clear if taking S. boulardii helps these standard treatments to work better.
A serious intestinal disease in premature infants (necrotizing enterocolitis or NEC). Most research shows that giving S. boulardii by mouth to preterm infants prevents NEC.
Diarrhea caused by rotavirus. Taking S. boulardii by mouth seems to reduce how long diarrhea lasts in children with diarrhea caused by rotavirus.
Travelers' diarrhea. Taking S. boulardii by mouth seems to reduce the risk of developing diarrhea while traveling.

Possibly Ineffective for

Blood infection (sepsis). Giving S. boulardii to preterm infants by mouth does not prevent sepsis.

There is interest in using S. boulardii for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: S. boulardii is likely safe when used for up to 15 months. It can cause gas in some people.

Special Precautions and Warnings

When taken by mouth: S. boulardii is likely safe when used for up to 15 months. It can cause gas in some people.

Pregnancy and breast-feeding: There isn't enough reliable information to know if S. boulardii is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: S. boulardii is possibly safe for most children when taken by mouth appropriately. But diarrhea in children should be evaluated by a healthcare professional before using S. boulardii. There isn't enough reliable information to know if S. boulardii is safe for very small premature infants.

Elderly: Older adults might have an increased risk of fungal infection when taking S. boulardii. Stay on the safe side and avoid use.

Digestive tract disease: S. boulardii has caused fungal infections in people with diseases of the digestive tract. If you have a digestive tract disease, talk with your healthcare provider before taking S. boulardii.

Weakened immune system: S. boulardii has caused fungal infections in people with weakened immune systems. In many cases, the infection was due to a catheter becoming contaminated. If you have a weakened immune system, talk with your healthcare provider before taking S. boulardii.

Yeast allergy: People with yeast allergy can be allergic to products containing S. boulardii. Stay on the safe side and avoid these products.

Interactions

Minor Interaction

Be watchful with this combination

Medications for fungal infections (Antifungals) interacts with SACCHAROMYCES BOULARDII
S. boulardii is a fungus. Medications for fungal infections help reduce fungus in and on the body. Taking S. boulardii with medications for fungal infections can reduce the effects of S. boulardii.

Dosing

In adults, S. boulardii has most often been taken by mouth in doses of 500-1000 mg (about 10-20 billion colony-forming units) daily for 4 weeks. In children, S. boulardii has most often been taken by mouth in doses of 250-500 mg (about 5-10 billion colony-forming units) for up to 4 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Jahangirifar M, Taebi M, Dolatian M. The effect of cinnamon on primary dysmenorrhea: a randomized, double-blind clinical trial. Complement Ther Clin Pract 2018;33:56-60. View abstract.

Jain S, Sangma T, Shukla SK, Mediratta PK. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci 2015;18(5):210-6. View abstract.

Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. View abstract.

Javed I, Faisal I, Rahman Z, et al. Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pak J Pharm Sci 2012;25(1):141-7. View abstract.

Sonmezer, M., Ozmen, B., Cil, A. P., Ozkavukcu, S., Tasci, T., Olmus, H., Atabekoglu, C. S. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online 2009;19(4):508-13. View abstract.

Srinivasan, M., Irving, B. A., Dhatariya, K., Klaus, K. A., Hartman, S. J., McConnell, J. P., Nair, K. S. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab 2009;94(3):761-4. View abstract.

Srinivasan, M., Irving, B. A., Frye, R. L., O'Brien, P., Hartman, S. J., McConnell, J. P., Nair, K. S. Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. J Clin Endocrinol Metab 2010;95(4):1617-25. View abstract.

Stangl, B., Hirshman, E., and Verbalis, J. Administration of dehydroepiandrosterone (DHEA) enhances visual-spatial performance in postmenopausal women. Behav Neurosci 2011;125(5):742-52. View abstract.

Stoll BA. Dietary supplements of dehydroepiandrosterone in relation to breast cancer risk. Eur J Clin Nutr 1999;53:771-5. View abstract.

Stomati M, Monteleone P, Casarosa E, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol 2000;14:342-63.. View abstract.

Stratigos AJ, Arndt KA, Dover JS. Advances in cutaneous aesthetic surgery. JAMA 1998;280:1397-98. View abstract.

Strous RD, Maayan R, Lapidus R, et al. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60:133-41.. View abstract.

Sugino, M., Ohsawa, N., Ito, T., Ishida, S., Yamasaki, H., Kimura, F., Shinoda, K. A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy. Neurology 1998;51(2):586-9. View abstract.

Suh-Burgmann, E., Sivret, J., Duska, L. R., Del Carmen, M., Seiden, M. V. Long-term administration of intravaginal dehydroepiandrosterone on regression of low-grade cervical dysplasia--a pilot study. Gynecol Obstet Invest 2003;55(1):25-31. View abstract.

Sun Y, Mao M, Sun L, et al. Treatment of osteoporosis in men using dehydroepiandrosterone sulfate.Chin Med J (Engl) 2002;115:402-4. View abstract.

Sunderland T, Merril CR, Harrington MG, et al. Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet 1989;2:570. View abstract.

Talaei A., Amini M., Siavash M., Zare M. The effect of dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance. Hormones (Athens) 2010;9(4):326-31. View abstract.

Tchernof A, Labrie F. Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. Eur J Endocrinol 2004;151:1-14. View abstract.

Teede, H. J., Dalais, F. S., McGrath, B. P. Dietary soy containing phytoestrogens does not have detectable estrogenic effects on hepatic protein synthesis in postmenopausal women. Am J Clin Nutr 2004;79(3):396-401. View abstract.

Thompson RD, Carlson M, Thompson RD, Carlson M. Liquid chromatographic determination of dehydroepiandrosterone (DHEA) in dietary supplement products. J AOAC Int 2000;83:847-57. View abstract.

Tilvis RS, Kahonen M, Harkonen M. Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population. (abstract) Aging (Milano) 1999;11:30-4. View abstract.

Tivesten A, Vandenput L, Carlzon D, et al. Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. J Am Coll Cardiol 2014;64(17):1801-10. View abstract.

Usiskin K. S., Butterworth S., Clore J. N., Arad Y., Ginsberg H. N., Blackard W. G., Nestler J. E. Lack of effect of dehydroepiandrosterone in obese men. Int J Obes 1990;14(5):457-63. View abstract.

Vacheron-Trystram, M. N., Cheref, S., Gauillard, J., Plas, J. [A case report of mania precipitated by use of DHEA]. Encephale 2002;28(6 Pt 1):563-6. View abstract.

van Thiel, S. W., Romijn, J. A., Pereira, A. M., Biermasz, N. R., Roelfsema, F., van Hemert, A., Ballieux, B., Smit, J. W. Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial. J Clin Endocrinol Metab 2005;90(6):3295-3303. View abstract.

Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. View abstract.

Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9. View abstract.

van Vollenhoven RF, Park JL, Genovese MC, et al. A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe lupus erythematosus. Lupus 1999;8:181-7. View abstract.

van Vollenhoven RF. Dehydroepiandrosterone in systemic lupus erythematosus. Rheum Dis Clin North Am 2000;26:349-62. View abstract.

Vierck JL, Icenoggle DL, Bucci L, Dodson MV. The effects of ergogenic compounds on myogenic satellite cells. Med Sci Sports Exerc 2003;35:769-76. View abstract.

Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) 2000;53:561-8. View abstract.

Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.JAMA 2004;292:2243-8. View abstract.

Virkki, L. M., Porola, P., Forsblad-d'Elia, H., Valtysdottir, S., Solovieva, S. A., Konttinen, Y. T. Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjogren's syndrome. Arthritis Care Res (Hoboken) 2010;62(1):118-24. View abstract.

Vogiatzi, M. G., Boeck, M. A., Vlachopapadopoulou, E., el-Rashid, R., New, M. I. Dehydroepiandrosterone in morbidly obese adolescents: effects on weight, body composition, lipids, and insulin resistance. Metabolism 1996;45(8):1011-5. View abstract.

von Muhlen D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int 2008;19(5):699-707. View abstract.

Kotowska, M., Albrecht, P., and Szajewska, H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment.Pharmacol.Ther. 3-1-2005;21(5):583-590. View abstract.

Mansour-Ghanaei, F., Dehbashi, N., Yazdanparast, K., and Shafaghi, A. Efficacy of saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol. 2003;9(8):1832-1833. View abstract.

- Corrêa NB, Penna FJ, Lima FM, Nicoli JR, Filho LA. Treatment of acute diarrhea with Saccharomyces boulardii in infants. J Pediatr Gastroenterol Nutr 2011;53(5):497-501. View abstract.

Adam J, Barret C, Barret-Bellet A, and et al. Essais cliniques controles en double insu de l'Ultra-Levure Lyophilisee. Etude multicentrique par 25 medecins de 388 cas. Gaz Med Fr 1977;84:2072-2078.

Al Faleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2014;(4):CD005496. View abstract.

Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. View abstract.

Asmat S, Shaukat F, Asmat R, Bakhat HFSG, Asmat TM. Clinical Efficacy Comparison of Saccharomyces Boulardii and Lactic Acid as Probiotics in Acute Pediatric Diarrhea. J Coll Physicians Surg Pak. 2018;28(3):214-217. View abstract.

Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. View abstract.

Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. View abstract.

Bafutto M, et al. Treatment of diarrhea-predominant irritable bowel syndrome with mesalamine and/or Saccharomyces boulardii. Arq Gastroenterol. 2013;50(4):304-309. View abstract.

Bassetti S, Frei R, Zimmerli W. Fungemia with Saccharomyces cerevisiae after treatment with Saccharomyces boulardii. Am J Med 1998;105:71-2. View abstract.

Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. View abstract.

Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2017;6(4). View abstract.

Bleichner G, Blehaut H, Mentec H, et al. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. Intensive Care Med 1997;23:517-23. View abstract.

Born, P., Lersch, C., Zimmerhackl, B., and Classen, M. [The Saccharomyces boulardii therapy of HIV-associated diarrhea]. Dtsch Med Wochenschr 5-21-1993;118(20):765. View abstract.

Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. View abstract.

Bourreille A, et al. Saccharomyces boulardii does not prevent relapse of Crohn's disease. Clin Gastroenterol Hepatol. 2013;11(8):982-987.

Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on bacterial overgrowth and composition of intestinal microbiota in IBS-D patients: results of a randomized pilot study. Dig Dis 2023. View abstract.

Buts JP, Corthier G, Delmee M. Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants. J Pediatr Gastroenterol Nutr 1993;16:419-25. View abstract.

Can M, Besirbellioglu BA, Avci IY, et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: A prospective study. Med Sci Monit 2006;12:PI19-22. View abstract.

Carstensen JW, Chehri M, Schønning K, et al. Use of prophylactic Saccharomyces boulardii to prevent Clostridium difficile infection in hospitalized patients: a controlled prospective intervention study. Eur J Clin Microbiol Infect Dis. 2018;37(8):1431-1439. View abstract.

Castagliuolo I, Riegler MF, Valenick L, et al. Saccharomyces boulardii protease inhibits the effects of clostridium difficile toxins A and B in human colonic mucosa. Infection and Immun 1999;67:302-7. View abstract.

Castagliuolo, I., LaMont, J. T., Nikulasson, S. T., and Pothoulakis, C. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect.Immun. 1996;64(12):5225-5232. View abstract.

Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. View abstract.

Cetina-Sauri G and Basto GS. Evaluacion terapeutica de Saccharomyces boulardii en ninos con diarrea aguda. Tribuna Med 1989;56:111-115.

Chang HY, Chen JH, Chang JH, Lin HC, Lin CY, Peng CC. Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis. PLoS One. 2017;12(2):e0171579. View abstract.

Chang YW, Park YM, Oh CH, et al. Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy. Korean J Intern Med. 2020;35(3):574-581. View abstract.

Chapoy, P. [Treatment of acute infantile diarrhea: controlled trial of Saccharomyces boulardii]. Ann Pediatr.(Paris) 1985;32(6):561-563. View abstract.

Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. View abstract.

Choi CH, Jo SY, Park HJ, Chang SK, Byeon JS, Myung SJ. A randomized, double-blind, placebo-controlled multicenter trial of Saccharomyces boulardii in irritable bowel syndrome: effect on quality of life. J Clin Gastroenterol. 2011;45(8):679-83. View abstract.

Chouraqui JP, Dietsch J, Musial C, and et al. Saccharomyces boulardii (SB) in the management of toddler diarrhea: a double-blind-placebo controlled study [abstract]. J Pediatr Gastroenterol Nutr 1995;20(4):463.

Cohen SH, Gerding DN, Johnson S, et al.; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31(5):431-55. View abstract.

Consoli ML, da Silva RS, Nicoli JR, et al. Randomized clinical trial: impact of oral administration of Saccharomyces boulardii on gene expression of intestinal cytokines in patients undergoing colon resection. JPEN J Parenter Enteral Nutr 2016;40(8):1114-21. View abstract.

Costalos, C., Skouteri, V., Gounaris, A., Sevastiadou, S., Triandafilidou, A., Ekonomidou, C., Kontaxaki, F., and Petrochilou, V. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum.Dev. 2003;74(2):89-96. View abstract.

Costanza AC, Moscavitch SD, Faria Neto HC, Mesquita ET. Probiotic therapy with Saccharomyces boulardii for heart failure patients: a randomized, double-blind, placebo-controlled pilot trial. Int J Cardiol. 2015;179:348-50. View abstract.

Cottrell J, Koenig K, Perfekt R, Hofmann R; Loperamide-Simethicone Acute Diarrhoea Study Team. Comparison of Two Forms of Loperamide-Simethicone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs R D. 2015;15(4):363-73. View abstract.

Cremonini F, Di Caro S, Covino M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97:2744-9. View abstract.

Cremonini, F., Di Caro, S., Santarelli, L., Gabrielli, M., Candelli, M., Nista, E. C., Lupascu, A., Gasbarrini, G., and Gasbarrini, A. Probiotics in antibiotic-associated diarrhoea. Dig.Liver Dis. 2002;34 Suppl 2:S78-S80. View abstract.

Czerucka D, Roux I, Rampal P. Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3',5'-cyclic monophosphate induction in intestinal cells. Gastroenterol 1994;106:65-72. View abstract.

D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002;324:1361. View abstract.

Dani C, Coviello C C, Corsini I I, Arena F, Antonelli A, Rossolini GM. Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review. AJP Rep. 2016;6(1):e25-9. View abstract.

Das S, Gupta PK, Das RR. Efficacy and Safety of Saccharomyces boulardii in Acute Rotavirus Diarrhea: Double Blind Randomized Controlled Trial from a Developing Country. J Trop Pediatr. 2016;62(6):464-470. View abstract.

Dauby N. Risks of Saccharomyces boulardii-Containing Probiotics for the Prevention of Clostridium difficile Infection in the Elderly. Gastroenterology. 2017;153(5):1450-1451. View abstract.

Dinleyici EC, Kara A, Dalgic N, et al. Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Benef Microbes. 2015;6(4):415-21. View abstract.

Duman, D. G., Bor, S., Ozutemiz, O., Sahin, T., Oguz, D., Istan, F., Vural, T., Sandkci, M., Isksal, F., Simsek, I., Soyturk, M., Arslan, S., Sivri, B., Soykan, I., Temizkan, A., Bessk, F., Kaymakoglu, S., and Kalayc, C. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol.Hepatol. 2005;17(12):1357-1361. View abstract.

Ehrhardt S, Guo N, Hinz R, et al. Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Open Forum Infect Dis. 2016;3(1):ofw011. View abstract.

Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105. View abstract.

Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8. View abstract.

Elmer GW, McFarland LV. Comment on the lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;37:307-8. View abstract.

Elmer GW, Moyer KA, Vega R, and et al. Evaluation of Saccharomyces boulardii for patients with HIV-related chronic diarrhoea and in healthy volunteers receiving antifungals. Microecology Ther 1995;25:23-31.

Erdeve, O., Tiras, U., and Dallar, Y. The probiotic effect of Saccharomyces boulardii in a pediatric age group. J Trop.Pediatr. 2004;50(4):234-236. View abstract.

Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6. View abstract.

Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014;134(1):e176-191. View abstract.

Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. View abstract.

Florez ID, Veroniki AA, Al Khalifah R, et al. Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. PLoS One. 2018;13(12):e0207701. View abstract.

Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3. View abstract.

Fu H, Li J, Xu X, Xia C, Pan Y. Effectiveness and safety of Saccharomyces boulardii for the treatment of acute gastroenteritis in the pediatric population: a systematic review and meta-analysis of randomized controlled trials. Comput Math Methods Med 2022;2022:6234858. View abstract.

Gao X, Wang Y, Shi L, Feng W, Yi K. Effect and safety of Saccharomyces boulardii for neonatal necrotizing enterocolitis in pre-term infants: A systematic review and meta-analysis. J Trop Pediatr. 2020:fmaa022. View abstract.

Gaon, D., Garcia, H., Winter, L., Rodriguez, N., Quintas, R., Gonzalez, S. N., and Oliver, G. Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina (B Aires) 2003;63(4):293-298. View abstract.

García-Collinot G, Madrigal-Santillán EO, Martínez-Bencomo MA, et al. Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis.Dig Dis Sci. 2019. View abstract.

Ghosh A, Sundaram B, Bhattacharya P, et al. Effect of Saccharomyces boulardii CNCM-I 3799 and Bacillus subtilis CU-1 on Acute Watery Diarrhea: A Randomized Double-Blind Placebo-Controlled Study in Indian Children. Pediatr Gastroenterol Hepatol Nutr 2021;24(5):423-431. View abstract.

Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015;(12):CD004827. View abstract.

Goldenberg JZ, Ma SS, Saxton JD, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2013;(5):CD006095. View abstract.

Goodman C, Keating G, Georgousopoulou E, Hespe C, Levett K. Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. BMJ Open 2021;11(8):e043054. View abstract.

Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003;15:697-8. View abstract.

Guslandi M, Mezzi G, Sorghi M, Testoni PA. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci 2000;45:1462-4. View abstract.

Harnett JE, Pyne DB, McKune AJ, Penm J, Pumpa KL. Probiotic supplementation elicits favourable changes in muscle soreness and sleep quality in rugby players. J Sci Med Sport. 2020:S1440-2440(20)30737-4. View abstract.

He XJ, Wang XL, Sun DJ, et al. The efficacy and safety of Saccharomyces boulardii in addition to antofloxacin-based bismuth quadruple therapy for Helicobacter pylori eradication: a single-center, prospective randomized-control study. Therap Adv Gastroenterol 2023;16:17562848221147763. View abstract.

Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, Johnsen B, Shekelle PG. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012 9;307(18):1959-69. View abstract.

Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9. View abstract.

Johnston BC, Ma SSY, Goldenberg JZ, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea. Ann Intern Med 2012;157:878-8. View abstract.

Karbownik MS, Kr&eogon;czy&nacute;ska J, Kwarta P, et al. Effect of supplementation with Saccharomyces boulardii on academic examination performance and related stress in healthy medical students: A randomized, double-blind, placebo-controlled trial. Nutrients. 2020;12(5):1469. View abstract.

Karbownik MS, Kreczynska J, Wiktorowska-Owczarek A, et al. Decrease in salivary serotonin in response to probiotic supplementation with Saccharomyces boulardii in healthy volunteers under psychological stress: Secondary analysis of a randomized, double-blind, placebo-controlled trial. Front Endocrinol (Lausanne) 2022;12:800023. View abstract.

Kimmey, M. B., Elmer, G. W., Surawicz, C. M., and McFarland, L. V. Prevention of further recurrences of Clostridium difficile colitis with Saccharomyces boulardii. Dig.Dis Sci 1990;35(7):897-901. View abstract.

Kirchhelle, A., Fruhwein, N., and Toburen, D. [Treatment of persistent diarrhea with S. boulardii in returning travelers. Results of a prospective study]. Fortschr Med 4-20-1996;114(11):136-140. View abstract.

Kollaritsch, H., Holst, H., Grobara, P., and Wiedermann, G. [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr.Med 3-30-1993;111(9):152-156. View abstract.

Krammer M, Karbach U. Antidiarrheal action of the yeast Saccharomyces boulardii in the rat small and large intestine by stimulating chloride absorption. Z Gastroenterol 1993;31:73-7.

Kurugol, Z. and Koturoglu, G. Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr. 2005;94(1):44-47. View abstract.

Lau CS, Chamberlain RS. Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Int J Gen Med. 2016;9:27-37. View abstract.

Lee KJ, Ryoo E, Lee YM, et al. Saccharomyces boulardii and lactulose for childhood functional constipation: a multicenter randomized controlled trial. J Neurogastroenterol Motil 2022;28(3):454-62. View abstract.

Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. View abstract.

Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhea in elderly patients. J Infect 1998;36:171-4. View abstract.

Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. View abstract.

Li Z, Zhu G, Li C, Lai H, Liu X, Zhang L. Which probiotic is the most effective for treating acute diarrhea in children? A Bayesian network meta-analysis of randomized controlled trials. Nutrients 2021;13(12):4319. View abstract.

Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. View abstract.

Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. View abstract.

Maupas JL, Champemont P, and Delforge M. [Treatment of irritable bowel syndrome with Saccharomyces boulardii - a double-blind, placebo controlled study]. Médicine et Chirurgie Digestives 1983;12(1):77-79.

McCullough MJ, Clemons KV, McCusker JH, Stevens DA. Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.). J Clin Microbiol 1998;36:2613-7. View abstract.

McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the infectious diseases society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):987-994. View abstract.

McFarland LV, Goh S. Are probiotics and prebiotics effective in the prevention of travellers' diarrhea: A systematic review and meta-analysis. Travel Med Infect Dis. 2019 Jan - Feb;27:11-19. View abstract.

McFarland LV, Karakan T, Karatas A. Strain-specific and outcome-specific efficacy of probiotics for the treatment of irritable bowel syndrome: A systematic review and meta-analysis. EClinicalMedicine. 2021;41:101154. View abstract.

McFarland LV, Surawicz C, Greenberg R, and et al. Saccharomyces boulardii and high dose vancomycin treats recurrent Clostridium difficile disease [abstract]. Am J Gastroenterol 1998;93(9):1694.

McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-8. View abstract.

McFarland LV, Surawicz CM, Greenberg RN, et al. Prevention of beta-lactam associated diarrhea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 1995;90:439-48. View abstract.

McFarland LV, SurawiczCM, Elmer GW, and et al. Multivariate analysis of the clinical efficacy of a biotherapeutic agent, Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea [abstract]. Am J Epidemiol 1993;138:649.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006;101:812-22. View abstract.

McFarland LV. Saccharomyces boulardii is not Saccharomyces cerevisiae. Clin Infect Dis 1996;22:200-1. View abstract.

Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380. View abstract.

Su GL, Ko CW, Bercik P, Falck-Ytter Y, et al. AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders. Gastroenterology. 2020;S0016-5085(20)34729-6. View abstract.

Suganthi V, Das AG. Role of Saccharomyces boulardii in reduction of neonatal hyperbilirubinemia. J Clin Diagn Res 2016;10(11):SC12-SC15. View abstract.

Surawicz CM, Elmer GW, Speelman P, et al. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989;96:981-8. View abstract.

Surawicz CM, McFarland LV, Elmer G, et al. Treatment of recurrent clostridium difficile colitis with vancomycin and Saccharomyces boulardii. Am J Gastroenterol 1989;84:1285-7. View abstract.

Surawicz, C. M. Treatment of recurrent Clostridium difficile-associated disease. Nat Clin Pract.Gastroenterol.Hepatol. 2004;1(1):32-38. View abstract.

Surawicz, C. M., McFarland, L. V., Greenberg, R. N., Rubin, M., Fekety, R., Mulligan, M. E., Garcia, R. J., Brandmarker, S., Bowen, K., Borjal, D., and Elmer, G. W. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin.Infect.Dis. 2000;31(4):1012-1017. View abstract.

Szajewska H, Horvath A, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Aliment Pharmacol Ther. 2015;41(12):1237-1245. View abstract.

Szajewska H, Kolodziej M, Zalewski BM. Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update. Aliment Pharmacol Ther. 2020. View abstract.

Szajewska H, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic -associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801. View abstract.

Szajewska H, Mrukowicz J. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2005;22:365-72. View abstract.

Tasteyre, A., Barc, M. C., Karjalainen, T., Bourlioux, P., and Collignon, A. Inhibition of in vitro cell adherence of Clostridium difficile by Saccharomyces boulardii. Microb.Pathog. 2002;32(5):219-225. View abstract.

Tempe, J. D., Steidel, A. L., Blehaut, H., Hasselmann, M., Lutun, P., and Maurier, F. [Prevention of diarrhea administering Saccharomyces boulardii during continuous enteral feeding]. Sem.Hop. 5-5-1983;59(18):1409-1412. View abstract.

Tsilika M, Thoma G, Aidoni Z, et al. A four-probiotic preparation for ventilator-associated pneumonia in multi-trauma patients: results of a randomized clinical trial. Int J Antimicrob Agents 2022;59(1):106471. View abstract.

US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.

van den Akker CHP, van Goudoever JB, Shamir R, Domellöf M, et al. Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2020;70(5):664-680. View abstract.

Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. View abstract.

Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12):1355-69. View abstract.

Weber G, Adamczyk A, Freytag S. [Treatment of acne with a yeast preparation]. Fortschr Med 1989;107:563-6. View abstract.

Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526. View abstract.

Xu L, Wang Y, Wang Y, et al. A double-blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I-745 in formula-fed preterm infants. J Pediatr (Rio J). 2016;92(3):296-301. View abstract.

Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9. View abstract.

Zhang J, Wan S, Gui Q. Comparison of safety, effectiveness and serum inflammatory factor indexes of Saccharomyces boulardii versus Bifidobacterium triple viable in treating children with chronic diarrhea: a randomized trial. Transl Pediatr 2021;10(6):1677-1685. View abstract.

Zhao Y, Yang Y, Aruna, et al. Saccharomyces boulardii Combined With Quadruple Therapy for Helicobacter pylori Eradication Decreased the Duration and Severity of Diarrhea: A Multi-Center Prospective Randomized Controlled Trial. Front Med (Lausanne) 2021;8:776955. View abstract.

Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24(5):e12651. View abstract.

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