Divi-divi (Caesalpinia bonduc) is a large shrub with thorny leaves. It grows in various countries where its seeds and leaves have been used to make medicine.
Ingredients in the divi-divi seeds might have activity against malaria, bacteria, and parasites.
People take divi-divi for malaria, fever, diabetes, infection of the intestines by parasites, and other conditions, but there is no good scientific evidence to support these uses.
Uses & Effectiveness
We currently have no information for DIVI-DIVI overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if divi-divi is safe or what the side effects might be.
Special Precautions and Warnings
When taken by mouth: There isn't enough reliable information to know if divi-divi is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if divi-divi is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for DIVI-DIVI overview.
Dosing
There isn't enough reliable information to know what an appropriate dose of divi-divi might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Iftikhar A, Aslam B, Iftikhar M, et aI. Effect of Caesalpinia bonduc polyphenol extract on alloxan-induced diabetic rats in attenuating hyperglycemia by upregulating insulin secretion and inhibiting JNK signaling pathway. Oxid Med Cell Longev. 2020 Mar 17;2020:9020219. View abstract.
Kalauni SK, Awale S, Tezuka Y, et al. Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship. Biol Pharm Bull. 2006;29(5):1050-2. View abstract.
Kousar S, Aslam B, Muhammad F, Khan JA. Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats. Pak J Pharm Sci. 2021 Jan;34(1(Supplementary)):307-11. View abstract.
Sharma SR, Dwivedi SK, Swarup D. Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. J Ethnopharmacol 1997;58:39-44. View abstract.
Simin K, Khaliq-Uz-Zaman SM, Ahmad VU. Antimicrobial activity of seed extracts and bondenolide from Caesalpinia bonduc (L.) Roxb. Phytother Res. 2001;15(5):437-40. View abstract.
Sindete M, Rharass T, Gbankoto A, et al. A comparative study of Caesalpinia bonduc (L.) Roxb. root extracts on sexual behaviour in male Wistar rats. Andrologia. 2021 Aug;53(7):e14072. View abstract.
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