Augustin, M., Andrees, U., Grimme, H., Schopf, E., and Simon, J. Effects of Mahonia aquifolium ointment on the expression of adhesion, proliferation, and activation markers in the skin of patients with psoriasis. Forsch.Komplementarmed. 1999;6 Suppl 2:19-21. View abstract.
Cernakova, M. and Kostalova, D. Antimicrobial activity of berberine--a constituent of Mahonia aquifolium. Folia Microbiol.(Praha) 2002;47(4):375-378. View abstract.
Cheng, Z., Pang, T., Gu, M., Gao, A. H., Xie, C. M., Li, J. Y., Nan, F. J., and Li, J. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim.Biophys.Acta 2006;1760(11):1682-1689. View abstract.
Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. View abstract.
Donsky, H. and Clarke, D. Relieva, a Mahonia aquifolium extract for the treatment of adult patients with atopic dermatitis. Am.J.Ther. 2007;14(5):442-446. View abstract.
Eaker, E. Y. and Sninsky, C. A. Effect of berberine on myoelectric activity and transit of the small intestine in rats. Gastroenterology 1989;96(6):1506-1513. View abstract.
Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. View abstract.
Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. View abstract.
Klovekorn, W., Tepe, A., and Danesch, U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. Int.J.Clin.Pharmacol.Ther. 2007;45(11):583-591. View abstract.
Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J. M., Lee, C. H., Oh, W. K., Kim, C. T., Hohnen-Behrens, C., Gosby, A., Kraegen, E. W., James, D. E., and Kim, J. B. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006;55(8):2256-2264. View abstract.
Lu, S. S., Yu, Y. L., Zhu, H. J., Liu, X. D., Liu, L., Liu, Y. W., Wang, P., Xie, L., and Wang, G. J. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol. 2009;200(2):159-165. View abstract.
Misik, V., Bezakova, L., Malekova, L., and Kostalova, D. Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium. Planta Med 1995;61(4):372-373. View abstract.
Miyazaki, H., Shirai, E., Ishibashi, M., Hosoi, K., Shibata, S., and Iwanaga, M. Quantitation of berberine chloride in human urine by use of selected ion monitoring in the field desorption mode. Biomed.Mass Spectrom. 1978;5(10):559-565. View abstract.
Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. View abstract.
Reuter, J., Wolfle, U., Weckesser, S., and Schempp, C. Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. J Dtsch.Dermatol.Ges. 2010;8(10):788-796. View abstract.
Rob C., Durk W. Isolation and characterization of microsatellite markers in the invasive shrub Mahonia aquifolium (Berberidacea) and their applicability in related species. Molecular Ecology Notes 2006;6(3):948-950.
Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. View abstract.
Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166(1):99-105. View abstract.
Wiesenauer M., Ludtke R. Mahonia aquifolium in patients with psoriasis vulgaris - an intraindividual study. 1996;3:231-235.
Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102. View abstract.
Yin, J., Gao, Z., Liu, D., Liu, Z., and Ye, J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol.Metab 2008;294(1):E148-E156. View abstract.
Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. View abstract.
Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J. L., Guang, L. X., Ying, Y., Xu, Y., Zhang, L., and Li, D. D. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull. 2008;31(6):1169-1176. View abstract.
Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466. View abstract.
Dong X, Li S, Chen J, Li Y, Wu Y, Zhang D. Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011-2014. Nutr J. 2020;19(1):25. View abstract.
Farinotti M, Vacchi L, Simi S, Di Pietrantonj C, Brait L, Filippini G. Dietary interventions for multiple sclerosis. Cochrane Database Syst Rev. 2012 Dec 12;12:CD004192. 2020 May 19;5:CD004192. View abstract.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: https://www.nap.edu/books/0309085373/html/.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: https://www.nap.edu/books/0309069351/html/
Gardner KG, Gebretsadik T, Hartman TJ, et al. Prenatal omega-3 and omega-6 polyunsaturated fatty acids and childhood atopic dermatitis. J Allergy Clin Immunol Pract. 2020;8(3):937-944. View abstract.
Gibson RA. Long-chain polyunsaturated fatty acids and infant development (editorial). Lancet 1999;354:1919.
Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5. View abstract.
Grytten E, Laupsa-Borge J, Bohov P, et al. Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. Clin Nutr 2021;40(5):2556-2575. View abstract.
Hanson S, Thorpe G, Winstanley L, Abdelhamid AS, Hooper L; PUFAH group. Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials. Br J Cancer. 2020;122(8):1260-1270. View abstract.
Harris WS, Tintle NL, Ramachandran VS. Erythrocyte n-6 fatty acids and risk for cardiovascular outcomes and total mortality in the Framingham heart study. Nutrients. 2018;10(12). pii: E2012. View abstract.
Henderson G, Crofts C, Schofield G. Linoleic acid and diabetes prevention. Lancet Diabetes Endocrinol. 2018;6(1):12-13. View abstract.
Hooper L, Al-Khudairy L, Abdelhamid AS, et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;11:CD011094. View abstract.
Jasani B, Simmer K, Patole SK, Rao SC. Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2017;3:CD000376. View abstract.
Kim Y, Kim J. N-6 polyunsaturated fatty acids and risk of cancer: Accumulating evidence from prospective studies. Nutrients. 2020;12(9):2523. View abstract.
Lapillonne A, Pastor N, Zhuang W, Scalabrin DMF. Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatr. 2014;14:168. View abstract.
Lee E, Kim H, Kim H, Ha EH, Chang N. Association of maternal omega-6 fatty acid intake with infant birth outcomes: Korean Mothers and Children's Environmental Health (MOCEH). Nutr J 2018;17(1):47. View abstract.
Lemoine C, Brigham E, Woo H, et al. Relationship between omega-3 and omega-6 fatty acid intake and chronic obstructive pulmonary disease morbidity. Ann Am Thorac Soc. 2020;17(3):378-381. View abstract.
Lemoine Soto CM, Woo H, Romero K, et al. Association of omega-3 and omega-6 fatty acid intake with inflammation and respiratory outcomes in COPD. Am J Resp Crit Care Med. 2018;197:A3139.
Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 1993;119:867-73. View abstract.
Lucas A, Stafford M, Morley R, et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomized trial. Lancet 1999;354:1948-54. View abstract.
Luo J, Ge H, Sun J, Hao K, Yao W, Zhang D. Associations of dietary ?-3, ?-6 fatty acids consumption with sleep disorders and sleep duration among adults. Nutrients 2021;13(5):1475. View abstract.
Malloy MJ, Kane JP. Agents used in hyperlipidemia. In: B. Katzung, ed. Basic and Clinical Pharmacology. 4th ed. Norwald, CT: Appleton and Lange, 1989.
Moon K, Rao SC, Schulzke SM, Patole SK, Simmer K. Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2016;12:CD000375. View abstract.
Nakamura H, Hara A, Tsujiguchi H, et al. Relationship between dietary n-6 fatty acid intake and hypertension: Effect of glycated hemoglobin levels. Nutrients. 2018;10(12). pii: E1825. View abstract.
Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8. View abstract.
Noguchi M, Rose DP, Earashi M, Miyazaki I. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 1995;52:265-71. View abstract.
Pawelczyk T, Trafalska E, Pawelczyk A, Kotlicka-Antczak M. Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls. Early Interv Psychiatry 2017;11(6):498-508. View abstract.
Richardson AJ, Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005;115:1360-6. View abstract.
Rose DP. The mechanistic rationale in support of dietary cancer prevention. Prev Med 1996;25:34-7. View abstract.
Rutting S, Papanicolaou M, Xenaki D, et al. Dietary ?-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD. Respir Res. 2018;19(1):211. View abstract.
Rutting S, Xenaki D, Lau E, et al. Dietary omega-6, but not omega-3, polyunsaturated or saturated fatty acids increase inflammation in primary lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol. 2018;314(6):L922-L935. View abstract.
Willatts P, Forsyth S, Agostoni C, Casaer P, Riva, E, Boehm G. Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. Am J Clin Nutr. 2013;98(suppl):536S-42S. View abstract.
Wu JHY, Marklund M, Imamura F, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39?740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol 2017;5(12):965-74. View abstract.
Ziemanski JF, Wolters LR, Jones-Jordan L, Nichols JJ, Nichols KK. Relation between dietary essential fatty acid intake and dry eye disease and meibomian gland dysfunction in postmenopausal women. Am J Ophthalmol. 2018;189:29-40. View abstract.
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