Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther 2004;19:521-7. View abstract.
Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. View abstract.
Leiva-Cala C, Lorenzo-Pouso AI, Centenera-Centenera B, et al. Clinical efficacy of an Aloe vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial. Odontology. 2020;108(3):470-478. View abstract.
Leng H, Pu L, Xu L, Shi X, Ji J, Chen K. Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-a-induced HaCaT cell proliferation and the underlying mechanism in psoriasis. Mol Med Rep 2018;18(3):3537-43. doi: 10.3892/mmr.2018.9319. View abstract.
Leong XY, Gopinath D, Syeed SM, Veettil SK, Shetty NY, Menon RK. Comparative Efficacy and Safety of Interventions for the Treatment of Oral Lichen Planus: A Systematic Review and Network Meta-Analysis. J Clin Med 2023;12(8):2763. View abstract.
Levin NJ, Erben Y, Li Y, Brigham TJ, Bruce AJ. A systematic review and meta-analysis comparing burn healing outcomes between silver sulfadiazine and Aloe vera. Cureus 2022;14(10):e30815. View abstract.
Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. Front Nutr. 2023;10:1116634. View abstract.
Lissoni P, Rovelli F, Brivio F, et al. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo. 2009;23:171-5. View abstract.
Lodi G, Carrozzo M, Furness S, et al. Interventions for treating oral lichen planus: a systematic review. Br J Dermatol. 2012;166:938-47. View abstract.
López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 2013;42(4):295-301. View abstract.
Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. View abstract.
Mahboub M, Aghazadeh Attari AM, Sheikhalipour Z, et al. A comparative study of the impacts of Aloe vera gel and silver sulfadiazine cream 1% on healing, itching and pain of burn wounds: A randomized clinical trial. J Caring Sci 2021;11(3):132-138. View abstract.
Malek Hosseini A, Rostam Khani M, Abdi S, Abdi S, Sharifi N. Comparison of aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial. BMC Res Notes 2024;17(1):25. View abstract.
Maleki A, Youseflu S. The effectiveness of Aloe vera on relief of irritation and nipple pain in lactating women: Systematic review and meta-analysis. Obstet Gynecol Int 2022;2022:7430581. View abstract.
Mansourian A, Momen-Heravi F, Saheb-Jamee M, et al. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. Am J Med Sci. 2011;342:447-51. View abstract.
Merchant TE, Bosley C, Smith J, et al. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. Radiat Oncol. 2007;2:45. View abstract.
Miller MB, Koltai PJ. Treatment of experimental frostbite with pentoxifylline and aloe vera cream. Arch Otolaryngol Head Neck Surg 1995;121:678-80. View abstract.
Molazem Z, Mohseni F, Younesi M, Keshavarzi S. Aloe vera gel and caesarean wound healing; a randomized controlled clinical trial. Glob J Health Sci 2014;7(1):203-9. View abstract.
Montaner JS, Gill J, Singer J, et al. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12:153-7. View abstract.
Moore Z, Cowman S. A systematic review of wound cleansing for pressure ulcers. J Clin Nurs. 2008;17:1963-72. View abstract.
Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. View abstract.
Muller MJ, Hollyoak MA, Moaveni Z, et al. Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Burns 2003;28:834-6.. View abstract.
Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978.
Najafian Y, Khorasani ZM, Najafi MN, Hamedi SS, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Curr Drug Discov Technol. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. View abstract.
Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. View abstract.
Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. View abstract.
Odes HS, Madar Z. A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation. Digestion. 1991;49:65-71. View abstract.
Olsen DL, Raub W, Bradley C, et al. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum 2001;28:543-7. View abstract.
Oyelami OA, Onayemi A, Oyedeji OA, et al. Preliminary study of effectiveness of aloe vera in scabies treatment. Phytother Res. 2009;23:1482-4. View abstract.
Panahi Y, Davoudi SM, Sahebkar A, et al. Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. Cutan Ocul Toxicol. 2012;31:95-103. View abstract.
Panahi Y, Rastgar N, Zamani A, Sahebkar A. Comparing the Therapeutic Effects of Aloe vera and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial. J Pharmacopuncture. 2020;23(3):173-178. View abstract.
Panahi Y, Sharif MR, Sharif A, et al. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal. 2012;2012:810234. View abstract.
Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31. View abstract.
Phillips T, Ongenae K, Kanj L, et al. A randomised study of an Aloe vera derivative gel dressing versus conventional treatment after shave biopsy excisions. Wounds 1995;7(5):200-202.
Plemons J, Rees TD Binnie WH, et al. Evaluation of acemannan in providing pain relief in patients with recurrent aphthous stomatitis. Wounds 1994;6:4.
Poordast T, Ghaedian L, Ghaedian L, et al. Aloe vera; a new treatment for atrophic vaginitis, a randomized double-blinded controlled trial. J Ethnopharmacol 2020:113760. Online ahead of print. View abstract.
Pradeep AR, Agarwal E, Naik SB. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. J Periodontol. 2012;83:797-804. View abstract.
Puataweepong P, Dhanachai M, Dangprasert S, et al. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Asian Biomedicine 2009;3(4):375-382.
Puvabanditsin P, Vongtongsri R. Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan. J Med Assoc Thai. 2005;88 Suppl 4:S173-6. View abstract.
Que S, Ma X, Yang T, He J. Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis. Jpn J Nurs Sci 2024;21(1):e12559. View abstract.
Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516. View abstract.
Bowry VW, Ingold KU, Stocker R. Vitamin E in human density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem J 1992;288:341-4. View abstract.
Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. View abstract.
Cook JD, Reddy MB. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 2001;73:93-8.. View abstract.
Cook JD. Food iron availability: back to the basics. Am J Clin Nutr 1998;67:593-4. View abstract.
de Assis SA, Fernances FP, Martins AB, de Faria Oliveira OM. Acerola: importance, culture conditions, production and biochemical aspects. Fruits 2008;63:93-101.
de Assis SA, Vellosa JC, Brunetti IL, et al. Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil. Int J Food Sci Nutr. 2009;60(5):439-48. View abstract.
Delva L, Schneider RG. Acerola (Malpighia emarginata DC): production, postharvest handling, nutrition, and biological activity. Food Rev Int 2013;29:107-26.
Denadai R, Souza FM, Valle MR. Fecal impaction by rectal acerola bezoar. Indian J Pediatr 2013;80(5):432-3. View abstract.
Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. View abstract.
Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467. View abstract.
Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. View abstract.
Fidler MC, Davidsson L, Zeder C, et al. Iron absorption from ferrous fumarate in adult women is influenced by ascorbic acid but not by Na2EDTA. Br J Nutr. 2003;90(6):1081-5. View abstract.
Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr 2000;3:125-50.. View abstract.
Fleming DJ, Jacques PF, Dallal GE, et al. Dietary determinants of iron stores in a free-living elderly population: The Framingham Heart Study. Am J Clin Nutr 1998;67:722-33.. View abstract.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: https://www.nap.edu/books/0309069351/html/.
Hanamura T, Mayama C, Aoki H, Hirayama Y, Shimizu M. Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem 2006;70(8):1813-20. View abstract.
Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. View abstract.
Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
Hu Y , Yin F , Liu Z , et al. Acerola polysaccharides ameliorate high-fat diet-induced non-alcoholic fatty liver disease through reduction of lipogenesis and improvement of mitochondrial functions in mice. Food Funct. 2020;11(1):1037-1048. View abstract.
Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. View abstract.
Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120. View abstract.
Kagan VE, Serbinova EA, Forte T, et al. Recycling of vitamin E in human low density lipoproteins. J Lipid Res 1992;33:385-97. View abstract.
Konrad G, Katz A. Are medication restrictions before FOBT necessary?: practical advice based on a systematic review of the literature. Can Fam Physician. 2012;58(9):939-48. View abstract.
Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8. View abstract.
Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. View abstract.
Lynch SR. Interaction of iron with other nutrients. Nutr Rev 1997;55:102-10.. View abstract.
Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. View abstract.
Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503. View abstract.
Moscoso CG. West Indian cherry - richest known source of natural vitamin C. Economic Botany 1956;10(3):280-94.
Motohashi N, Wakabayashi H, Kurihara T, et al. Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions. Phytother Res 2004;18(3):212-23. View abstract.
Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. View abstract.
Pino JA, Marbot R. Volatile flavor constituents of acerola (Malpighia emarginata DC.) fruit. J Agric Food Chem 2001;49:5880-2. View abstract.
Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. View abstract.
Raulf-Heimsoth M, Stark R, Sander I, et al. Anaphylactic reaction to apple juice containing acerola: cross-reactivity to latex due to prohevein. J Allergy Clin Immunol 2002;109(4):715-6. View abstract.
Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. View abstract.
Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. View abstract.
Stralsjo L, Alklint C, Olsson ME, Sjoholm I. Total folate content and retention in rosehips (Rosa ssp.) after drying. J Agric Food Chem 2003;51:4291-5. View abstract.
Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. View abstract.
Thankachan P, Walczyk T, Muthayya S, et al. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr. 2008;87(4):881-6. View abstract.
Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. View abstract.
Uchida E, Kondo Y, Amano A, et al. Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: comparison in healthy Japanese subjects. Biol Pharm Bull 2011;34:1744-7. View abstract.
Van Steirteghem AC, Robertson EA, Young DS. Influence of large doses of ascorbic acid on laboratory test results. Clin Chem. 1978;24(1):54-7. View abstract.
Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. View abstract.
Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. View abstract.
Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
Select a condition to view a list of vitamins
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
Licensed from Therapeutic Research Center, LLC
Copyright © 1995-2024 by Therapeutic Research Center, LLC. All Rights Reserved.