GREATER BURNET: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Greater burnet (Sanguisorba officinalis) is a plant commonly found in Europe and Asia. The roots are used in Traditional Chinese Medicine (TCM).

Greater burnet might work as a drying agent to help stop bleeding. Some ingredients in greater burnet might also help reduce wrinkles and improve wound healing.

People use greater burnet for aging skin, varicose veins, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness

We currently have no information for GREATER BURNET overview.

Side Effects

When taken by mouth: There isn't enough reliable information to know if greater burnet is safe or what the side effects might be.

When applied to the skin: Greater burnet dried root extract is possibly safe when used in a lotion for up to 8 weeks. It's not clear what the side effects might be.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if greater burnet is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

We currently have no information for GREATER BURNET overview.

Dosing

There isn't enough reliable information to know what an appropriate dose of greater burnet might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Bastow, K. F., Bori, I. D., Fukushima, Y., Kashiwada, Y., Tanaka, T., Nonaka, G., Nishioka, I., and Lee, K. H. Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis. Planta Med 1993;59(3):240-245. View abstract.

Hachiya, A., Kobayashi, A., Ohuchi, A., Kitahara, T., and Takema, Y. The inhibitory effect of an extract of Sanguisorba officinalis L. on ultraviolet B-induced pigmentation via the suppression of endothelin-converting enzyme-1alpha. Biol.Pharm.Bull. 2001;24(6):688-692. View abstract.

Liu, X., Cui, Y., Yu, Q., and Yu, B. Triterpenoids from Sanguisorba officinalis. Phytochemistry 2005;66(14):1671-1679. View abstract.

Han JH, Kim M, Choi HJ, et al. The oral administration of Sanguisorba officinalis extract improves physical performance through LDHA modulation. Molecules 2021;26(6):1579. View abstract.

Lachowicz S, Oszmianski J, Rapak A, Ochmian I. Profile and content of phenolic compounds in leaves, flowers, roots, and stalks of Sanguisorba officinalis L. determined with the LC-DAD-ESI-QTOF-MS/MS analysis and their in vitro antioxidant, antidiabetic, antiproliferative potency. Pharmaceuticals (Basel) 2020;13(8):191. View abstract.

Li C, Gong L, Jiang Y, et al. Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT/NF-?B/ STAT3 pathway uncovered by single-cell RNA sequencing. Phytomedicine 2023;120:155052. View abstract.

Nam Y, Kim M, Erdenebileg S, et al. Sanguisorba officinalis L. Ameliorates Hepatic Steatosis and Fibrosis by Modulating Oxidative Stress, Fatty Acid Oxidation, and Gut Microbiota in CDAHFD-Induced Mice. Nutrients 2023;15(17):3779. View abstract.

Negm WA, El-Kadem AH, Elekhnawy E, et al. Wound-Healing Potential of Rhoifolin-Rich Fraction Isolated from Sanguisorba officinalis Roots Supported by Enhancing Re-Epithelization, Angiogenesis, Anti-Inflammatory, and Antimicrobial Effects. Pharmaceuticals (Basel) 2022;15(2):178. View abstract.

Shen X, Zhang W, Peng C, et al. In vitro anti-bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection. Chin Med 2021;16(1):33. View abstract.

Song J, Zeng J, Zheng S, et al. Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage. Phytother Res 2023;37(9):4265-4281. View abstract.

Wei F, Yang C, Wu L, Sun J, Wang Z, Wang Z. Simultaneous Determination and Pharmacokinetics Study of Three Triterpenes from Sanguisorba officinalis L. in Rats by UHPLC-MS/MS. Molecules 2022;27(17):5412. View abstract.

Wu C, Yao M, Li W, et al. Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of Sanguisorba officinalis L. Extract. Molecules. 2018;23(11):2980. View abstract.

Yoshida H, Yamazaki K, Komiya A, et al. Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling. Int J Cosmet Sci. 2019;41(1):12-20. View abstract.

Yun MY, Bae EY, Lee SW, Yim SH, Ly SY, Choi HJ. Anti-photoaging effect of skin cream manufactured with ziyuglycoside I isolated from Sanguisorba officinalis on ultraviolet B-induced hairless mice. Biosci Biotechnol Biochem. 2019 Jul;83(7):1197-1204. View abstract.

Zhang H, Chen J, Cen Y. Burn wound healing potential of a polysaccharide from Sanguisorba officinalis L. in mice. Int J Biol Macromol. 2018;112:862-867. View abstract.

Zheng Y, Lee SY, Lee Y, et al. Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress. Antioxidants (Basel) 2023;12(4):882. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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