TERMINALIA ARJUNA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Terminalia arjuna is a tree. Its bark is traditionally used in Ayurvedic medicine.

The bark of the Terminalia arjuna tree contains chemicals that might stimulate the heart. It might also have effects that lower cholesterol and blood pressure.

People use Terminalia arjuna for chest pain, asthma, athletic performance, heart disease, high cholesterol, high blood pressure, obesity, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse Terminalia arjuna with other Terminalia species, including Terminalia chebula and Terminalia bellirica. These are not the same.

Uses & Effectiveness

We currently have no information for TERMINALIA ARJUNA overview.

Side Effects

When taken by mouth: Terminalia arjuna is possibly safe when used for up to 3 months. But it shouldn't be used without medical supervision. It can have significant effects on the heart.

Special Precautions and Warnings

When taken by mouth: Terminalia arjuna is possibly safe when used for up to 3 months. But it shouldn't be used without medical supervision. It can have significant effects on the heart.

Pregnancy and breast-feeding: There isn't enough reliable information to know if Terminalia arjuna is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Terminalia arjuna might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.

Surgery: Terminalia arjuna might increase the risk of bleeding during surgery. Stop taking Terminalia arjuna at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with TERMINALIA ARJUNA
Terminalia arjuna might slow blood clotting. Taking Terminalia arjuna along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with TERMINALIA ARJUNA
Some medications are changed and broken down by the liver. Terminalia arjuna might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with TERMINALIA ARJUNA
Some medications are changed and broken down by the liver. Terminalia arjuna might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with TERMINALIA ARJUNA
Some medications are changed and broken down by the liver. Terminalia arjuna might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Terminalia arjuna has most often been used by adults in doses of 500 mg by mouth three times daily for up to 3 months. Keep in mind that Terminalia arjuna can affect the heart and should only be used under medical supervision. Speak with a healthcare provider before use.

View References

REFERENCES:

Anand KK, Singh B, Saxena AK, et al. 3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity. Pharmacol Res 1997;36:315-21. View abstract.

Arseculeratne SN, Gunatilaka AA, Panabokke RG. Studies of medicinal plants of Sri Lanka. Part 14: Toxicity of some traditional medicinal herbs. J Ethnopharmacol 1985;13:323-35. View abstract.

Bharani A, Ganguli A, Mathur LK, Jamra Y, Raman PG. Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate. Indian Heart J. 2002;54(2):170-175. View abstract.

Bharani A, Ganguly A, Bhargava KD. Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure. Int J Cardiol 1995;49:191-9. View abstract.

Chevallier A. Encyclopedia of Medicinal Plants. New York, NY: DK Publishing, 1996.

Dwivedi S, Agarwal MP. Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug, in coronary artery disease. J Assoc Physicians India 1994;42:287-9. View abstract.

Dwivedi S, Jauhari R. Beneficial effects of Terminalia arjuna in coronary artery disease. Indian Heart J 1997;49:507-10. View abstract.

el-Mekkawy S, Meselhy MR, Kusumoto IT, et al. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull (Tokyo) 1995;43:641-8. View abstract.

Girandola RN, Srivastava S. Effect of E-OJ-01 on cardiac conditioning in young exercising adults: A randomized controlled trial. Am J Ther. 2017;24(3):e298-e307. View abstract.

Gupta R, Singhal S, Goyla A, Sharma VN. Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomized placebo-controlled trial. J Assoc Physicians India. 2001;49:231-235. View abstract.

Hamada S, Kataoka T, Woo JT, et al. Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity. Biol Pharm Bull 1997;20:1017-9. View abstract.

Jagtap AG, Karkera SG. Potential of the aqueous extract of Terminalia chebula as an anticaries agent. J Ethnopharmacol 1999;68:299-306. View abstract.

Kakadia N, Kanaki N. Anti-osteoporotic effect of Terminalia arjuna (Roxb.) Wight & Arn. In bilateral ovariectomized induced post-menopausal osteoporosis in experimental rats. J Complement Integr Med 2021. View abstract.

Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res 1995;27:19-37. View abstract.

Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.

Maulik SK, Wilson V, Seth S, Bhargava B, Dua P, Ramakrishnan S, Katiyar CK. Clinical efficacy of water extract of stem bark of Terminalia arjuna (Roxb. Ex DC.) Wight & Arn. In patients of chronic heart failure: a double-blind randomized controlled trial. Phytomedicine. 2016 Oct 15;23(11):1211-9. View abstract.

Pettit GR, Hoard MS, Doubek DL, et al. Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). J Ethnopharmacol 1996;53:57-63. View abstract.

Phadke SA, Kulkarni SD. Screening of in vitro antibacterial activity of Terminalia chebula, Eclapta alba and Ocimum sanctum. Indian J Med Sci 1989;43:113-7. View abstract.

Ram A, Lauria P, Gupta R, et al. Hypocholesterolaemic effects of Terminalia arjuna tree bark. J Ethnopharmacol 1997;55:165-9. View abstract.

Saleem S, Ansari AH, Ansari A. Effect of Arjun Chal on cardiovascular risk factors - a randomized controlled clinical trial. J Complement Integr Med 2021;19(1):145-154. View abstract.

Sato Y, Oketani H, Singyouchi K, et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula RETS. against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull 1997;20:401-4. View abstract.

Shaila HP, Udupa SL, Udupa AL. Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis. Int J Cardiol 1998;67:119-214. View abstract.

Shiraki K, Yukawa T, Kurokawa M, Kageyama S. [Cytomegalovirus infection and its possible treatment with herbal medicines]. Nippon Rinsho 1998;56:156-60. View abstract.

Srivastava S, Girandola RN, Abedon B. Effect of E-OJ-01 on left ventricular ejection fraction and myocardial oxygen consumption: A randomized, double-blind, placebo-controlled study. J Multidiscip Healthc 2022;15:2511-2525. View abstract.

Suthienkul O, Miyazaki O, Chulasiri M, et al. Retroviral reverse transcriptase inhibitory activity in Thai herbs and spices: screening with Moloney murine leukemia viral enzyme. Southeast Asian J Trop Med Public Health 1993;24:751-5. View abstract.

Thakur CP, Thakur B, Singh S, et al. The Ayurvedic medicines Haritaki, Amala and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int J Cardiol 1988;21:167-75. View abstract.

Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. View abstract.

Yukawa TA, Kurokawa M, Sato H, et al. Prophylactic treatment of cytomegalovirus infection with traditional herbs. Antiviral Res 1996;32:63-70. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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TERMINALIA ARJUNA - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Side Effects

Special Precautions and Warnings

Interactions

Moderate Interaction

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with TERMINALIA ARJUNA

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with TERMINALIA ARJUNA

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with TERMINALIA ARJUNA

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with TERMINALIA ARJUNA

Dosing

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