[Saffron for the mood]. Praxis (Bern.1994.) 6-29-2005;94(26-27):1090. View abstract.
Abe, K. and Saito, H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother.Res 2000;14(3):149-152. View abstract.
Abe, K., Sugiura, M., Shoyama, Y., and Saito, H. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res 3-16-1998;787(1):132-138. View abstract.
Ahmad, A. S., Ansari, M. A., Ahmad, M., Saleem, S., Yousuf, S., Hoda, M. N., and Islam, F. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem.Behav. 2005;81(4):805-813. View abstract.
Asdaq, S. M. and Inamdar, M. N. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl.Biochem.Biotechnol. 2010;162(2):358-372. View abstract.
Aung, H. H., Wang, C. Z., Ni, M., Fishbein, A., Mehendale, S. R., Xie, J. T., Shoyama, C. Y., and Yuan, C. S. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp.Oncol. 2007;29(3):175-180. View abstract.
Aytekin, A. and Acikgoz, A. O. Hormone and microorganism treatments in the cultivation of saffron (Crocus sativus L.) plants. Molecules. 2008;13(5):1135-1147. View abstract.
Boskabady, M. H., Shafei, M. N., Shakiba, A., and Sefidi, H. S. Effect of aqueous-ethanol extract from Crocus sativus (saffron) on guinea-pig isolated heart. Phytother.Res 2008;22(3):330-334. View abstract.
Carmona, M., Zalacain, A., Pardo, J. E., Lopez, E., Alvarruiz, A., and Alonso, G. L. Influence of different drying and aging conditions on saffron constituents. J Agric.Food Chem. 5-18-2005;53(10):3974-3979. View abstract.
Chen, X., Krakauer, T., Oppenheim, J. J., and Howard, O. M. Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation. J Altern.Complement Med. 2004;10(3):519-526. View abstract.
Chryssanthi, D. G., Lamari, F. N., Iatrou, G., Pylara, A., Karamanos, N. K., and Cordopatis, P. Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res 2007;27(1A):357-362. View abstract.
Das, I., Chakrabarty, R. N., and Das, S. Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac.J Cancer Prev. 2004;5(1):70-76. View abstract.
Dhar, A., Mehta, S., Dhar, G., Dhar, K., Banerjee, S., Van Veldhuizen, P., Campbell, D. R., and Banerjee, S. K. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol.Cancer Ther. 2009;8(2):315-323. View abstract.
el Daly, E. S. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharm.Belg. 1998;53(2):87-93. View abstract.
Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003;84(2-3):199-203. View abstract.
Ferrence, S. C. and Bendersky, G. Therapy with saffron and the goddess at Thera. Perspect.Biol.Med. 2004;47(2):199-226. View abstract.
Garcia-Olmo, D. C., Riese, H. H., Escribano, J., Ontanon, J., Fernandez, J. A., Atienzar, M., and Garcia-Olmo, D. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. Nutr.Cancer 1999;35(2):120-126. View abstract.
Ghazavi, A., Mosayebi, G., Salehi, H., and Abtahi, H. Effect of ethanol extract of saffron (Crocus sativus L.) on the inhibition of experimental autoimmune encephalomyelitis in C57bl/6 mice. Pak.J Biol.Sci. 5-1-2009;12(9):690-695. View abstract.
Gregory, M. J., Menary, R. C., and Davies, N. W. Effect of drying temperature and air flow on the production and retention of secondary metabolites in saffron. J Agric.Food Chem. 7-27-2005;53(15):5969-5975. View abstract.
Hosseinzadeh, H. and Noraei, N. B. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother.Res 2009;23(6):768-774. View abstract.
Hosseinzadeh, H. and Sadeghnia, H. R. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine. 2007;14(4):256-262. View abstract.
Hosseinzadeh, H. and Sadeghnia, H. R. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci. 2005;8(3):394-399. View abstract.
Hosseinzadeh, H. and Talebzadeh, F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia 2005;76(7-8):722-724. View abstract.
Hosseinzadeh, H. and Younesi, H. M. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC.Pharmacol 3-15-2002;2:7. View abstract.
Hosseinzadeh, H., Abootorabi, A., and Sadeghnia, H. R. Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs. DNA Cell Biol. 2008;27(12):657-664. View abstract.
Hosseinzadeh, H., Ziaee, T., and Sadeghi, A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine. 2008;15(6-7):491-495. View abstract.
Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009; View abstract.
Kanakis, C. D., Tarantilis, P. A., Tajmir-Riahi, H. A., and Polissiou, M. G. Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties. J Agric.Food Chem. 2-7-2007;55(3):970-977. View abstract.
Laabich, A., Vissvesvaran, G. P., Lieu, K. L., Murata, K., McGinn, T. E., Manmoto, C. C., Sinclair, J. R., Karliga, I., Leung, D. W., Fawzi, A., and Kubota, R. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol.Vis.Sci. 2006;47(7):3156-3163. View abstract.
Li, C. Y. and Wu, T. S. Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity. J Nat.Prod. 2002;65(10):1452-1456. View abstract.
Liakopoulou-Kyriakides, M. and Skubas, A. I. Characterization of the platelet aggregation inducer and inhibitor isolated from Crocus sativus. Biochem.Int. 1990;22(1):103-110. View abstract.
Liu, T. Z. and Qian, Z. Y. [Pharmacokinetics of crocetin in rats]. Yao Xue.Xue.Bao. 2002;37(5):367-369. View abstract.
Ma SP, Liu BL. Pharmacological studies of glycosides of saffron crocus (Crocus sativus): effects on blood coagulation, platelet aggregation, and thrombosis. Chinese Traditional and Herbal Drugs (China) 1999;30:196-198.
Maccarone, R., Di Marco, S., and Bisti, S. Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. Invest Ophthalmol.Vis.Sci. 2008;49(3):1254-1261. View abstract.
Magesh, V., Singh, J. P., Selvendiran, K., Ekambaram, G., and Sakthisekaran, D. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol.Cell Biochem. 2006;287(1-2):127-135. View abstract.
Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. View abstract.
Moraga, A. R., Nohales, P. F., Perez, J. A., and Gomez-Gomez, L. Glucosylation of the saffron apocarotenoid crocetin by a glucosyltransferase isolated from Crocus sativus stigmas. Planta 2004;219(6):955-966. View abstract.
Moraga, A. R., Rambla, J. L., Ahrazem, O., Granell, A., and Gomez-Gomez, L. Metabolite and target transcript analyses during Crocus sativus stigma development. Phytochemistry 2009;70(8):1009-1016. View abstract.
Moshiri, E., Basti, A. A., Noorbala, A. A., Jamshidi, A. H., Hesameddin, Abbasi S., and Akhondzadeh, S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine. 2006;13(9-10):607-611. View abstract.
Mousavi, S. H., Tavakkol-Afshari, J., Brook, A., and Jafari-Anarkooli, I. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem.Toxicol 2009;47(8):1909-1913. View abstract.
Naghizadeh, B., Boroushaki, M. T., Vahdati, Mashhadian N., and Mansouri, M. T. Protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rats. Iran Biomed.J 2008;12(2):93-100. View abstract.
Nair, S. C., Panikkar, K. R., and Parthod, R. K. Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide. Cancer Biother. 1993;8(4):339-343. View abstract.
Abe, S., Maruyama, N., Hayama, K., Inouye, S., Oshima, H., and Yamaguchi, H. Suppression of neutrophil recruitment in mice by geranium essential oil. Mediators.Inflamm. 2004;13(1):21-24. View abstract.
Abe, S., Maruyama, N., Hayama, K., Ishibashi, H., Inoue, S., Oshima, H., and Yamaguchi, H. Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils. Mediators.Inflamm. 2003;12(6):323-328. View abstract.
Akdogan, M., Kilinc, I., Oncu, M., Karaoz, E., and Delibas, N. Investigation of biochemical and histopathological effects of Mentha piperita L. and Mentha spicata L. on kidney tissue in rats. Hum.Exp Toxicol. 2003;22(4):213-219. View abstract.
Akdogan, M., Tamer, M. N., Cure, E., Cure, M. C., Koroglu, B. K., and Delibas, N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother.Res 2007;21(5):444-447. View abstract.
Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. View abstract.
Arumugam, P. Priya N. Subathra M. Ramesh A. Environmental Toxicology & Pharmacology 2008;26(1):92-95.
Baker, J. R., Bezance, J. B., Zellaby, E., and Aggleton, J. P. Chewing gum can produce context-dependent effects upon memory. Appetite 2004;43(2):207-210. View abstract.
Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298. View abstract.
Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. View abstract.
Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. View abstract.
Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. View abstract.
de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268. View abstract.
Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. View abstract.
Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017-1020. View abstract.
Grant, P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother.Res 2010;24(2):186-188. View abstract.
Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348. View abstract.
Imai, H., Osawa, K., Yasuda, H., Hamashima, H., Arai, T., and Sasatsu, M. Inhibition by the essential oils of peppermint and spearmint of the growth of pathogenic bacteria. Microbios 2001;106 Suppl 1:31-39. View abstract.
Johnson, A. J. and Miles, C. Chewing gum and context-dependent memory: the independent roles of chewing gum and mint flavour. Br.J Psychol. 2008;99(Pt 2):293-306. View abstract.
Johnson, A. J. and Miles, C. Evidence against memorial facilitation and context-dependent memory effects through the chewing of gum. Appetite 2007;48(3):394-396. View abstract.
Kumar, V., Kural, M. R., Pereira, B. M., and Roy, P. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Food Chem Toxicol. 2008;46(12):3563-3570. View abstract.
Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II). Contact Dermatitis 2001;44(6):344-346. View abstract.
Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. View abstract.
Miles, C. and Johnson, A. J. Chewing gum and context-dependent memory effects: a re-examination. Appetite 2007;48(2):154-158. View abstract.
Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. View abstract.
Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. View abstract.
Pratap, S, Mithravinda, Mohan, YS, Rajoshi, C, and Reddy, PM. Antimicrobial activity and bioautography of essential oils from selected Indian medicinal plants (MAPS-P-410). International Pharmaceutical Federation World Congress 2002;62:133.
Rafii, F. and Shahverdi, A. R. Comparison of essential oils from three plants for enhancement of antimicrobial activity of nitrofurantoin against enterobacteria. Chemotherapy 2007;53(1):21-25. View abstract.
Rasooli, I., Shayegh, S., and Astaneh, S. The effect of Mentha spicata and Eucalyptus camaldulensis essential oils on dental biofilm. Int J Dent.Hyg. 2009;7(3):196-203. View abstract.
Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. View abstract.
Sokovic, M. D., Vukojevic, J., Marin, P. D., Brkic, D. D., Vajs, V., and van Griensven, L. J. Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities. Molecules. 2009;14(1):238-249. View abstract.
Soliman, K. M. and Badeaa, R. I. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem.Toxicol 2002;40(11):1669-1675. View abstract.
Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. View abstract.
Torney, L. K., Johnson, A. J., and Miles, C. Chewing gum and impasse-induced self-reported stress. Appetite 2009;53(3):414-417. View abstract.
Tucha, O., Mecklinger, L., Maier, K., Hammerl, M., and Lange, K. W. Chewing gum differentially affects aspects of attention in healthy subjects. Appetite 2004;42(3):327-329. View abstract.
Wilkinson, L., Scholey, A., and Wesnes, K. Chewing gum selectively improves aspects of memory in healthy volunteers. Appetite 2002;38(3):235-236. View abstract.
Yu, T. W., Xu, M., and Dashwood, R. H. Antimutagenic activity of spearmint. Environ Mol.Mutagen. 2004;44(5):387-393. View abstract.
Zhao, C. Z., Wang, Y., Tang, F. D., Zhao, X. J., Xu, Q. P., Xia, J. F., and Zhu, Y. F. [Effect of Spearmint oil on inflammation, oxidative alteration and Nrf2 expression in lung tissue of COPD rats]. Zhejiang.Da.Xue.Xue.Bao.Yi.Xue.Ban. 2008;37(4):357-363. View abstract.
Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8. View abstract.
Akdogan M, Ozguner M, Kocak A, et al. Effects of peppermint teas on plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels and testicular tissue in rats. Urology 2004;64:394-8. View abstract.
Bardaweel SK, Bakchiche B, ALSalamat HA, Rezzoug M, Gherib A, Flamini G. Chemical composition, antioxidant, antimicrobial and antiproliferative activities of essential oil of Mentha spicata L. (Lamiaceae) from Algerian Saharan atlas. BMC Complement Altern Med. 2018;18(1):201. View abstract.
Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. View abstract.
Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10. View abstract.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Falcone PH, Nieman KM, Tribby AC, et al. The attention-enhancing effects of spearmint extract supplementation in healthy men and women: a randomized, double-blind, placebo-controlled, parallel trial. Nutr Res. 2019;64:24-38. View abstract.
Falcone PH, Tribby AC, Vogel RM, et al. Efficacy of a nootropic spearmint extract on reactive agility: a randomized, double-blind, placebo-controlled, parallel trial. J Int Soc Sports Nutr. 2018;15(1):58. View abstract.
Gunatheesan S, Tam MM, Tate B, et al. Retrospective study of oral lichen planus and allergy to spearmint oil. Australas J Dermatol 2012;53:224-8. View abstract.
Herrlinger KA, Nieman KM, Sanoshy KD, et al. Spearmint extract improves working memory in men and women with age-associated memory impairment. J Altern Complement Med. 2018;24(1):37-47. View abstract.
Hunt R, Dienemann J, Norton HJ, Hartley W, Hudgens A, Stern T, Divine G. Aromatherapy as treatment for postoperative nausea: a randomized trial. Anesth Analg 2013;117(3):597-604. View abstract.
Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. View abstract.
Ting S, Nguyen J, Palmer A, Rosemary Nixon AM. Contact sensitisation in oral lichen planus: An Australian perspective. Contact Dermatitis 2023. View abstract.
Vejdani R, Shalmani HR, Mir-Fattahi M, et al. The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study. Dig Dis Sci. 2006 Aug;51:1501-7. View abstract.
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