WHEAT BRAN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Wheat bran is the outer layers of the wheat grain kernel. It's separated from the inner layers during milling. It's rich in soluble and insoluble fiber.

Wheat bran has laxative effects that can increase stool volume and bowel frequency. It also contains proteins, fats, carbohydrates, minerals, vitamins, and antioxidants.

People use wheat bran for constipation, hemorrhoids, and irritable bowel syndrome (IBS). It is also used for colon cancer, diabetes, high cholesterol, and many other conditions, but there is no good scientific evidence to support most of these uses.

Wheat is considered a major food allergen in the US. Wheat contents, including wheat bran, must be labeled on packaged foods and supplement products.

Uses & Effectiveness

Possibly Effective for

Constipation. Taking wheat bran by mouth seems to help restore normal bowel function in people with mild constipation.
Hemorrhoids. Taking wheat bran by mouth might help reduce the risk of getting hemorrhoids in some people.
A long-term disorder of the large intestine that causes stomach pain (irritable bowel syndrome or IBS). Taking wheat bran by mouth seems to improve bowel function in some people with IBS.

Possibly Ineffective for

Colon cancer, rectal cancer. Taking wheat bran by mouth doesn't seem to reduce the risk for colon or rectal cancer.

There is interest in using wheat bran for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Wheat bran is likely safe when used in doses up to 30 grams daily for up to 3 months. It's usually well-tolerated. Side effects might include gas and stomach discomfort.

Special Precautions and Warnings

When taken by mouth: Wheat bran is likely safe when used in doses up to 30 grams daily for up to 3 months. It's usually well-tolerated. Side effects might include gas and stomach discomfort.

Pregnancy and breast-feeding: Wheat bran is likely safe when taken by mouth during pregnancy and breast-feeding.

Children: Wheat bran is likely safe when taken by mouth in doses up to 10 grams daily. It has been used safely for up to 2 years.

Interactions

We currently have no information for WHEAT BRAN overview.

Dosing

Wheat bran is a source of dietary fiber. Recommendations for dietary fiber intake vary by age.

As medicine, wheat bran has most often been used by adults in doses of 20-30 grams by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Anderson JW, Floore TL, Geil PB, et al. Hypocholesterolemic effects of different bulk-forming hydrophilic fibers as adjuncts to dietary therapy in mild to moderate hypercholesterolemia. Arch Intern Med. 1991 Aug;151:1597-602. View abstract.

Anderson JW, Jones AE, Riddell-Mason S. Ten different dietary fibers have significantly different effects on serum and liver lipids of cholesterol-fed rats. J Nutr 1994;124:78-83. View abstract.

Anderson JW, Riddell-Mason S, Gustafson NJ, et al. Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia. Am J Clin Nutr 1992;56:93-8. View abstract.

Anderson JW, Zettwoch N, Feldman T, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic men. Arch Intern Med 1988;148:292-6. View abstract.

Arlian LG, Vyszenski-Moher DL, Lawrence AT, et al. Antigenic and allergenic analysis of psyllium seed components. J Allergy Clin Immunol 1992;89:866-76.. View abstract.

Arthurs Y, Fielding JF. Double blind trial of ispaghula/poloxamer in the Irritable Bowel Syndrome. Ir Med J. 1983 May;76(5):253. View abstract.

Ashraf W, Park F, Lof J, et al. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther. 1995 Dec;9(6):639-47. View abstract.

Ashraf W, Pfeiffer RF, Park F, et al. Constipation in Parkinson's disease: objective assessment and response to psyllium. Mov Disord 1997;12:946-51.. View abstract.

Attaluri A, Donahoe R, Valestin J, et al. Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Aliment Pharmacol Ther. 2011 Apr;33(7):822-8.View abstract.

Bacha AA, Din ZU, Khan I. Effect of Psyllium husk fiber and lifestyle modification on human body insulin resistance. Nutr Metab Insights 2022;15:11786388221107797. View abstract.

Belknap D, Davidson LJ, Smith CR. The effects of psyllium hydrophilic mucilloid on diarrhea in enterally fed patients. Heart Lung 1997;26:229-37.. View abstract.

Bell LP, Hectorn KJ, Reynolds H, Hunninghake DB. Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia. Am J Clin Nutr. 1990 Dec;52:1020-6. View abstract.

Bell LP, Hectorne K, Reynolds H, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid. Adjunct therapy to a prudent diet for patients with mild to moderate hypercholesterolemia. JAMA 1989;261:3419-23. View abstract.

Bernedo N, García M, Gastaminza G, et al. Allergy to laxative compound (Plantago ovata seed) among health care professionals. J Investig Allergol Clin Immunol 2008;18(3):181-9. View abstract.

Bijkerk CJ, de Wit NJ, Muris JW, et al. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 2009 Aug 27;339:b3154. View abstract.

Bliss DZ, Jung HJ, Savik K, et al. Supplementation with dietary fiber improves fecal incontinence. Nurs Res 2001;50:203-13. View abstract.

Bobrove AM. Misoprostol, diarrhea, and psyllium mucilloid. Ann Intern Med 1990;112:386. View abstract.

Bonithon-Kopp C, Kronborg O, Giacosa A, et al. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet 2000;356:1300-6. View abstract.

Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999;69:30-42. View abstract.

Burke V, Hodgson JM, Beilin LJ, et al. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension 2001;38:821-6.. View abstract.

Cavaliere H, Floriano I, Medeiros-Neto G. Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid). Int J Obes Relat Metab Disord 2001;25:1095-9. View abstract.

Chan EK, Schroeder DJ. Psyllium in hypercholesterolemia. Ann Pharmacother 1995;29:625-7. View abstract.

Chapman ND, Grillage MG, Mazumder R, et al. A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open, prospectively randomised, parallel group study. Br J Clin Pract. 1990 Nov;44(11):461-6. View abstract.

Cheskin LJ, Kamal N, Crowell MD, et al. Mechanisms of constipation in older persons and effects of fiber compared with placebo. J Am Geriatr Soc 1995;43:666-9.. View abstract.

Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. View abstract.

Clark CCT, Salek M, Aghabagheri E, Jafarnejad S. The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Korean J Intern Med 2020 Feb 19. doi: 10.3904/kjim.2019.049. Online ahead of print. View abstract.

Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2016.

Code of Federal Regulations, Title 21 (21CFR 101.81). Chapter IB, part 101E, section 101.81 "Health claims: soluble fiber from certain foods and risk of coronary heart disease (CHD)." Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=101.81. Accessed December 3, 2016.

Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed December 3, 2016.

Cook IJ, Irvine EJ, Campbell D, et al. Effect of dietary fiber on rectosigmoid motility in patients with irritable bowel syndrome: A controlled, crossover study. Gastroenterology 1990;98:66-72. View abstract.

Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.

Abd Elmoneim Elmadbouly M. Effect of Wheat Bran on Anthropometric Measures, Serum Glucose and Lipid Profile in Type 2 Diabetes Patients. Pak J Biol Sci 2021;24(3):345-349. View abstract.

Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. N Engl J Med 2000;342:1156-62. View abstract.

Anon. Consensus statement on cereals, fibre and colorectal and breast cancers. Proceedings of the European Cancer Prevention consensus meeting. Santa Margheritia, Italy, 2-5 October 1997. Eur J Cancer Prev 1998;7:S1-83. View abstract.

Anti M, Pignataro G, Armuzzi A, et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology 1998;45:727-32.. View abstract.

Aoe S, Nakamura F, Fujiwara S. Effect of wheat bran on fecal butyrate-producing bacteria and wheat bran combined with barley on Bacteroides abundance in Japanese healthy adults. Nutrients 2018;10(12)1980. doi: 10.3390/nu10121980. View abstract.

Badiali D, Corazziari E, Habib FI, et al. Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. Dig Dis Sci 1995;40:349-56.. View abstract.

Balasubramanian R, Johnson EJ, Marlett JA. Effect of wheat bran on bowel function and fecal calcium in older adults. J Am Coll Nutr. 1987;6(3):199-208. doi: 10.1080/07315724.1987.10720182. View abstract.

Bavarsad N, Mapar MA, Safaezadeh M, Latifi SM. A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma. J Cosmet Dermatol. 2020. View abstract.

Chandalia M, Garg A, Lutjohann D, et al. Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 2000;342:1392-8. View abstract.

Dalile B, La Torre D, Kalc P, et al. Extruded Wheat Bran Consumption Increases Serum Short-Chain Fatty Acids but Does Not Modulate Psychobiological Functions in Healthy Men: A Randomized, Placebo-Controlled Trial. Front Nutr 2022;9:896154. View abstract.

De Paepe K, Verspreet J, Rezaei MN, et al. Modification of wheat bran particle size and tissue composition affects colonisation and metabolism by human faecal microbiota. Food Funct 2019;10(1):379-96. doi: 10.1039/c8fo01272e. View abstract.

Deroover L, Vázquez-Castellanos JF, Vandermeulen G, et al. Wheat bran with reduced particle size increases serum SCFAs in obese subjects without improving health parameters compared with a maltodextrin placebo. Am J Clin Nutr 2021;114(4):1328-1341. View abstract.

Fairweather-Tait SJ. The effect of different levels of wheat bran on iron absorption in rats from bread containing similar amounts of phytate. Br J Nutr. 1982;47(2):243-9. View abstract.

Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-information/food-allergen-labeling-and-consumer-protection-act-2004-falcpa.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: https://www.nap.edu/books/0309085373/html/.

Fuchs CS, Giovannucci EL, Colditz GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999;340:169-76. View abstract.

Govers MJ, Gannon NJ, Dunshea FR, et al. Wheat bran affects the site of fermentation of resistant starch and luminal indexes related to colon cancer risk: a study in pigs. Gut 1999;45:840-7. View abstract.

Griffenberg L, Morris M, Atkinson N, Levenback C. The effect of dietary fiber on bowel function following radical hysterectomy: a randomized trial. Gynecol Oncol 1997;66:417-24.. View abstract.

Hallberg L, Rossander L, Skånberg AB. Phytates and the inhibitory effect of bran on iron absorption in man. Am J Clin Nutr. 1987;45(5):988-96. View abstract.

Hallfrisch J, Scholfield DJ, Behall KM. Blood pressure reduced by whole grain diet containing barley or whole wheat and brown rice in moderately hypercholesterolemic men. Nutr Res 2003;23:1631-42.

Helton WS; SSAT, AGA, ASGE Consensus Panel. 2001 consensus statement on benign anorectal disease. J Gastrointest Surg 2002;6:302-3.

Ishikawa H, Akedo I, Otani T, et al. Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int J Cancer 2005;116(5):762-7. View abstract.

Jenkins DJ, Kendall CW, Augustin LS, et al. Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes. Diabetes Care 2002;25:1522-8.. View abstract.

Jensen SL, Harling H, Tange G, et al. Maintenance bran therapy for prevention of symptoms after rubber band ligation of third-degree haemorrhoids. Acta Chir Scand 1988;154:395-98. View abstract.

Junejo SA, Zhang L, Yang L, et al. Anti-hyperlipidemic and hepatoprotective properties of wheat bran with different particle sizes. J Sci Food Agric 2019;99(4):1990-6. doi: 10.1002/jsfa.9397. View abstract.

Lai H, Li Y, He Y, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes 2023;15(1):2197837. View abstract.

Lei L, Chen J, Liu Y, Wang L, Zhao G, Chen ZY. Dietary wheat bran oil is equally as effective as rice bran oil in reducing plasma cholesterol. J Agric Food Chem 2018;66(11):2765-74. doi: 10.1021/acs.jafc.7b06093. View abstract.

Maffei HV, Vicentini AP. Prospective evaluation of dietary treatment in childhood constipation: high dietary fiber and wheat bran intake are associated with constipation amelioration. J Pediatr Gastroenterol Nutr. 2011 Jan;52(1):55-9. doi: 10.1097/MPG.0b013e3181e2c6e2. View abstract.

Martinez TM, Wachsmuth HR, Meyer RK, et al. Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats. Nutr Metab (Lond) 2023;20(1):44. View abstract.

McRorie J, Kesler J, Bishop L, et al. Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms. Am J Gastroenterol 2000;95:1244-52. View abstract.

Meiller L, Sauvinet V, Breyton AE, et al. Metabolic signature of (13)C-labeled wheat bran consumption related to gut fermentation in humans: a pilot study. Eur J Nutr 2023;62(6):2633-2648. View abstract.

Parisi GC, Zilli M, Miani MP, et al. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Dig Dis Sci 2002;47:1697-704.. View abstract.

Petroski W, Minich DM. Is there such a thing as "anti-nutrients"? A narrative review of perceived problematic plant compounds. Nutrients. 2020;12(10):E2929. View abstract.

Rakvaag E, Fuglsang-Nielsen R, Bach Knudsen KE, Hermansen K, Gregersen S. The combination of whey protein and dietary fiber does not alter low-grade inflammation or adipose tissue gene expression in adults with abdominal obesity. Rev Diabet Stud. 2019;15:83-93. View abstract.

Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N Engl J Med 2000;342:1149-55. View abstract.

Stamatikos AD, Davis JE, Shay NF, Ajuwon KM, Deyhim F, Banz WJ. Consuming diet supplemented with either red wheat bran or soy extract changes glucose and insulin levels in female obese zucker rats. Int J Vitam Nutr Res. 2020;90(1-2):23-32. View abstract.

Tuncil YE, Thakkar RD, Arioglu-Tuncil S, Hamaker BR, Lindemann SR. Fecal microbiota responses to bran particles are specific to cereal type and in vitro digestion methods that mimic upper gastrointestinal tract passage. J Agric Food Chem 2018;66(47):12580-93. doi: 10.1021/acs.jafc.8b03469. View abstract.

Van Horn L. Fiber, lipids, and coronary heart disease. A statement for healthcare professionals from the Nutr Committee, Am Heart Assn. Circulation 1997;95:2701-4. View abstract.

Yan T, Shi L, Liu T, et al. Diet-rich in wheat bran modulates tryptophan metabolism and AhR/IL-22 signalling mediated metabolic health and gut dysbacteriosis: A novel prebiotic-like activity of wheat bran. Food Res Int 2023;163:112179. View abstract.

Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995;35:495-508. View abstract.

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