ASTRAGALUS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Astragalus (Astragalus membranaceus) is a type of flowering plant. The root has been used for centuries in traditional Chinese Medicine (TCM).

Astragalus is considered an adaptogen. Adaptogens are a class of natural substances that are believed to stimulate the body's resistance to physical, environmental, and emotional stressors. The chemicals in astragalus also seem to stimulate the immune system and reduce swelling.

People commonly use astragalus for hay fever, diabetes, kidney disease, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using astragalus for COVID-19.

There are many species of astragalus. Some species contain a nerve toxin and have been linked to livestock poisonings. These include Astragalus lentiginosus, Astragalus mollissimus, and others. But these species usually aren't found in dietary supplements. Most astragalus supplements contain Astragalus membranaceus. Also, don't confuse astragalus with tragacanth. These are different plants.

Uses & Effectiveness

Possibly Effective for

Reducing side effects of chemotherapy. Early research suggests that giving astragalus intravenously (by IV) or using Chinese herbal mixtures containing astragalus might reduce nausea, vomiting, diarrhea, and bone marrow suppression (a decrease in the cells that provide immunity) that is associated with chemotherapy treatments.
Diabetes. Early research suggests that astragalus, given intravenously (by IV) or taken by mouth as a combination product, might help control blood sugar and insulin levels in people with type 2 diabetes.

Side Effects

When taken by mouth: Astragalus is possibly safe for most adults. Doses of up to 60 grams daily have been safely used for up to 4 months. Astragalus is usually well-tolerated.

When applied to the skin: There isn't enough reliable information to know if astragalus is safe or what the side effects might be.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if astragalus is safe to use when pregnant or breast-feeding. But some research in animals suggests that it can be toxic during pregnancy and to the fetus. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other immune system conditions: Astragalus might make the immune system more active. This could worsen the symptoms of auto-immune diseases. Avoid using astragalus if you have any of these conditions.

Interactions

Moderate Interaction

Be cautious with this combination

Cyclophosphamide interacts with ASTRAGALUS
Cyclophosphamide is used to make the immune system less active. Astragalus increases the activity of the immune system. Taking astragalus along with cyclophosphamide might decrease the effects of cyclophosphamide.
Medications that decrease the immune system (Immunosuppressants) interacts with ASTRAGALUS
Astragalus can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking astragalus along with these medications might decrease the effects of these medications.
Lithium interacts with ASTRAGALUS
Taking astragalus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs) interacts with ASTRAGALUS
Astragalus might lower blood sugar levels. Taking astragalus along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Dosing

Astragalus is available as the dried root, as an extract, and as a liquid decoction. It is also often used in combination with other herbs. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

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Cassileth, B. R., Rizvi, N., Deng, G., Yeung, K. S., Vickers, A., Guillen, S., Woo, D., Coleton, M., and Kris, M. G. Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemother.Pharmacol. 2009;65(1):67-71. View abstract.

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Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med 2012;35(1):E1-11. View abstract.

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Chen, M. L., Liu, W. J., Wang, C. Y., Zhu, X. M., Yin, J. F., Wang, D. X., and Liu, P. [Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats]. Zhongguo Zhong.Yao Za Zhi. 2003;28(8):746-751. View abstract.

Chen, P. Y., Zhou, F., Chen, W. L., Ceng, Y., and Luo, L. Y. Clinical observation on the effect of Xinshu Capsule (XC) in treating frequent ventricular extrasystoles due to viral myocarditis and the influence on NO, NOS AND SOD [in Chinese]. Chinese Journal of Current Traditional and Western Medicine 2005;3(10):893-895.

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Cho, J. H., Cho, C. K., Shin, J. W., Son, J. Y., Kang, W., and Son, C. G. Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. Complement Ther.Med 2009;17(3):141-146. View abstract.

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Fu, S., Zhang, J., Menniti-Ippolito, F., Gao, X., Galeotti, F., Massari, M., Hu, L., Zhang, B., Ferrelli, R., Fauci, A., Firenzuoli, F., Shang, H., Guerra, R., and Raschetti, R. Huangqi injection (a traditional Chinese patent medicine) for chronic heart failure: a systematic review. PLoS.One. 2011;6(5):e19604. View abstract.

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He, Z. P., Wang, D. Z., Shi, L. Y., and Wang, Z. Q. Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. J Tradit.Chin Med 1986;6(3):187-190. View abstract.

Hoo, R. L., Wong, J. Y., Qiao, C., Xu, A., Xu, H., and Lam, K. S. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) 2010;7:67. View abstract.

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Huh, J. E., Kwon, N. H., Baek, Y. H., Lee, J. D., Choi, D. Y., Jingushi, S., Kim, K. I., and Park, D. S. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Int Immunopharmacol. 2009;9(12):1357-1365. View abstract.

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Wang, F. Twenty-eight cases of diabetic foot ulcer and gangrene treated with the Chinese herbal medicine combined with injection of ahylsantinfarctase. J.Tradit.Chin Med. 2002;22(1):3-4. View abstract.

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Wang, G., Liu, C. T., Wang, Z. L., Yan, C. L., Luo, F. M., Wang, L., and Li, T. Q. Effects of Astragalus membranaceus in promoting T-helper cell type 1 polarization and interferon-gamma production by up-regulating T-bet expression in patients with asthma. Chin J Integr.Med 2006;12(4):262-267. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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ASTRAGALUS - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Possibly Effective for

Side Effects

Special Precautions and Warnings

Interactions

Moderate Interaction

Cyclophosphamide interacts with ASTRAGALUS

Medications that decrease the immune system (Immunosuppressants) interacts with ASTRAGALUS

Lithium interacts with ASTRAGALUS

Medications for diabetes (Antidiabetes drugs) interacts with ASTRAGALUS

Dosing