DEVIL'S CLAW - Uses, Side Effects, and More

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Rashid, M., Durie, P., Andrew, M., Kalnins, D., Shin, J., Corey, M., Tullis, E., and Pencharz, P. B. Prevalence of vitamin K deficiency in cystic fibrosis. Am.J.Clin.Nutr. 1999;70(3):378-382. View abstract.

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Sasaki, N., Kusano, E., Takahashi, H., Ando, Y., Yano, K., Tsuda, E., and Asano, Y. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J.Bone Miner.Metab 2005;23(1):41-47. View abstract.

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Sato, Y., Honda, Y., Kaji, M., Asoh, T., Hosokawa, K., Kondo, I., and Satoh, K. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002;31(1):114-118. [RETRACTED]. View abstract.

Sato, Y., Honda, Y., Kuno, H., and Oizumi, K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone 1998;23(3):291-296. [RETRACTED]. View abstract.

Sato, Y., Kaji, M., Tsuru, T., Satoh, K., and Kondo, I. Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson's disease. Arch.Phys.Med.Rehabil. 2002;83(1):86-91. [RETRACTED]. View abstract.

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Baghdikian, B., Guiraud-Dauriac, H., Ollivier, E., N'Guyen, A., Dumenil, G., and Balansard, G. Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria. Planta Med 1999;65(2):164-166. View abstract.

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Betancor-Fernandez, A., Perez-Galvez, A., Sies, H., and Stahl, W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol 2003;55(7):981-986. View abstract.

Bhattacharya A and Bhattacharya SK. Anti-oxidative activity of Harpagophytum procumbens. Br J Phytother 1998;72:68-71.

Biller, A. Ergebnisse sweier randomisieter kontrollierter. Phyto-pharmaka 2002;7:86-88.

Boje, K., Lechtenberg, M., and Nahrstedt, A. New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Planta Med 2003;69(9):820-825. View abstract.

Brien, S., Lewith, G. T., and McGregor, G. Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 2006;12(10):981-993. View abstract.

Chrubasik S and Eisenberg E. Treatment of rheumatic pain with Kampo medicine in Europe. The Pain Clinic 1999;11(3):171.

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Chrubasik S, Sporer F, Wink M, and et al. Zum wirkstoffgehalt in arzneimitteln aus harpagophytum procumbens. Forsch Komplementärmed 1996;3:57-63.

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Chrubasik, S. Addendum to the ESCOP monograph on Harpagophytum procumbens. Phytomedicine. 2004;11(7-8):691-695. View abstract.

Chrubasik, S., Conradt, C., and Roufogalis, B. D. Effectiveness of Harpagophytum extracts and clinical efficacy. Phytother.Res. 2004;18(2):187-189. View abstract.

Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2):118-129. View abstract.

Clarkson, C., Campbell, W. E., and Smith, P. In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (devil's claw). Planta Med 2003;69(8):720-724. View abstract.

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Gobel, H., Heinze, A., Ingwersen, M., Niederberger, U., and Gerber, D. [Effects of Harpagophytum procumbens LI 174 (devil's claw) on sensory, motor und vascular muscle reagibility in the treatment of unspecific back pain]. Schmerz. 2001;15(1):10-18. View abstract.

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Jadot G and Lecomte A. Activite anti-inflammatoire d'Harpagophytum procumbens DC. Lyon Mediteranee Med Sud-Est 1992;28:833-835.

Kaszkin, M., Beck, K. F., Koch, E., Erdelmeier, C., Kusch, S., Pfeilschifter, J., and Loew, D. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine. 2004;11(7-8):585-595. View abstract.

Kikuchi T. New iridoid glucosides from Harpagophytum procumbens. Chem Pharm Bull 1983;31:2296-2301.

Kundu, J. K., Mossanda, K. S., Na, H. K., and Surh, Y. J. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett. 1-31-2005;218(1):21-31. View abstract.

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Leblan, D., Chantre, P., and Fournie, B. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. Joint Bone Spine 2000;67(5):462-467. View abstract.

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Loew, D., Mollerfeld, J., Schrodter, A., Puttkammer, S., and Kaszkin, M. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin.Pharmacol.Ther. 2001;69(5):356-364. View abstract.

Munkombwe, N. M. Acetylated phenolic glycosides from Harpagophytum procumbens. Phytochemistry 2003;62(8):1231-1234. View abstract.

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Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. View abstract.

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