Schizophrenia Onset: When Do Symptoms Usually Start?

Medically Reviewed by Zilpah Sheikh, MD on August 08, 2024
10 min read
A Face of Tardive DyskinesiaBrian Smuda's head nods progressed into full-body spasms, a debilitating side effect of his long-term use of medications for Tourette's. Medicines and movement therapy can help, but deep brain stimulation, a brain surgery, greatly reduced his involuntary movements. Check him out on the slopes now!281

BRIAN SMUDA: TD,

or tardive dyskinesia,

is pretty much uncontrollable,

jerky movements of the body.

Smacking of the lips, licking,

or jaw movements.

I have Tourette's, and I kind

of feel like it's just

an increased version

of Tourette's.



So back in the age of five,

we went to my primary care

doctor and noticed I was doing

a little head nod.

We didn't know at the time that

that would be Tourette's.

When I graduated college

in 2008, I said to my parents

that I didn't want to have

the Tourette's anymore.



I thought, you know, I can get

treated for that with medicine.

After four years, in 2012, I

started getting anxiety, panic

attacks.

So I got prescribed

some antipsychotics, which

didn't much work well for me.



When I took that, that would

lead to the jerking of the neck

and then the head rubbing,

uncontrollable arm spasms.

Those are the three

major symptoms, which we noticed

in, like 2012 and '13.

As the symptoms developed,

they were trying to treat

the Tourette's as well as

the anxiety issue.



There was about 11 medications

over a six-year span,

trying to treat what the doctors

at first, and for a long period

of that time thought

was just worse Tourette's as I

got older.



My movement has spread

to my whole body.

I just woke up.

I can't do anything.



ANTHONY ROSSEAU: There were

good days, and then there were

bad days.

It'd be like, OK, he wouldn't

have any movement at all,

and it'd be great.

And then the next day

his twitches were so bad

that he'd be throwing up.



BRIAN SMUDA: I just showered.

Threw up four times.

These are

the involuntary movements I have

going right now.



I went to a local hospital

in Boston, and they said,

for the first time

ever, tardive dyskinesia.

When they pinpointed this was

caused by the medicine,

from there we were able to focus

on getting steps done

to counteract what was going on.



So there are other options

for the-- treating the TD.

Medicines or movement therapy

and stuff like that.

Mine was, though, the deep brain

stimulation.



ANTHONY ROSSEAU: He'd hit

a wall, and that'd be it,

or there's gonna

be a light at the end

of the tunnel.

With the surgery,

that was the light at the end

of the tunnel.



BRIAN SMUDA: Getting

into the DBS program,

I was referred

by my psychiatrist.



[SOFT ACOUSTIC MUSIC]



And from June 26th to August

2nd, that's all the time

it took for me to go through all

the exams

to see if you would be

a candidate for that procedure.

Post-procedure and getting

the right settings for me

have definitely improved

the movements.



ANTHONY ROSSEAU: Yeah, he still

does have body tics,

and he's still moving.

But the progress that's been

made, it's just fascinating.



BRIAN SMUDA: The brain

operation, for me,

was a huge stepping stone that

allowed me to get back to living

again.

I was able to ski 86 days

after the initial brain surgery,

which was opening day

of my favorite mountain

in Vermont.

When I go skiing, it totally

lets me escape my mind

of tardive dyskinesia.



ANTHONY ROSSEAU: When we're

on the slopes, when he's going

down the mountain,

there's no tics or anything

like that.

Since post-surgery, quality

of life has improved.

As long as that keeps up,

I think that he's gonna

be successful.



BRIAN SMUDA: What I can

recommend to people that either

are not yet diagnosed or are

currently diagnosed newly

or it's 10 years on

and they haven't seen

any improvement,

follow what your movement

disorder specialist says

and just keep on pushing on.

Hope for tomorrow.



After the deep brain

stimulation, there's days where

I wake up, I feel around, like,

80% better.

There's days where you feel

depressed in a funk.

When I feel in a funk, I still

have the hope that my day gets

better.



If I go out and do something

joyful I can, ultimately, step

that up a little bit

and, you know, sit there

and just be nice, prompt,

and relaxed.

If you're hopeful enough

and you go out and go

for a hike, you go for a bike

ride, you do something that

brings you joy,

you can appreciate the highs

in life that you can get

from simple joys.

Brian Smuda./delivery/aws/0d/0a/0d0a1933-eec3-3a01-b5e6-e6231e4e7932/091e9c5e81e9f659_funded-doc-td-brian_,4500k,2500k,1000k,750k,400k,.mp403/31/2020 08:00:00 AM18001200funded doc td brian video/webmd/consumer_assets/site_images/article_thumbnails/video/funded_doc_td_brian_video/1800x1200_funded_doc_td_brian_video.jpg091e9c5e81e9f659

Schizophrenia usually takes hold after puberty. Most people are diagnosed in their late teens to early 30s. It's rare to develop this mental health disorder before age 12 or after age 40.

Schizophrenia onset tends to be slightly earlier for those assigned male at birth than for those assigned female. On average, men are diagnosed in their late teens to early 20s. Women tend to get diagnosed in their late 20s to early 30s.

No one knows exactly why schizophrenia onset often happens during late adolescence, but there are many theories.

Research suggests the disorder is caused by a combination of something in your genes and things that happen while your brain is developing. If you're vulnerable, the start of symptoms may be set off by a change in your environment or your body.

Your brain changes and develops during your late teens and early 20s. These shifts might trigger the disease in people who are at a risk of it.

Some scientists believe it has to do with development in an area of the brain called the frontal cortex. Others think it has to do with too many connections between nerve cells being eliminated as the brain matures.

Hormones also play a major role in puberty. One theory is that women get schizophrenia later than men because they go through puberty earlier and the hormone estrogen might somehow protect them.

Adolescence is also a time when many people experiment with marijuana and other recreational drugs. Research has linked the use of drugs, especially cannabis, to a higher risk of schizophrenia.

Know how to recognize the signs of schizophrenia in teens.

Schizophrenia can be hard to diagnose for a few reasons. One is that people with the disorder often don't realize they're ill, so they're unlikely to go to a doctor for help.

Another issue is that many of the changes leading up to schizophrenia, called the prodrome, can mirror other normal life changes. For example, a teen who's developing the illness might drop their group of friends and take up with new ones. They may also have trouble sleeping or suddenly start coming home with poor grades. That's not unusual for any teen and may not raise a red flag.

Other subtle signs can include mood swings, irritability, spending time alone, and trouble staying on task.

The vast majority of people with those behaviors will not go on to develop schizophrenia, and it's very hard to figure out who might. Doctors have a number of assessments they use to try to determine who's at most risk so they can get treatment as early as possible.

Early intervention with medications or psychotherapy could keep the condition from getting worse for at least some amount of time.

Learn more about the prodrome phase of schizophrenia.

Schizophrenia is a syndrome. People with schizophrenia have several types of symptoms:

Hallucinations. You hear voices or see or smell things that others say aren't there. The voices might criticize or threaten you. They might tell you to do things you otherwise wouldn't.

Delusions. You believe things that aren't true, even when others show you proof or share facts that explain why your beliefs are wrong. Delusions can seem bizarre to others. For example, you might think that the TV is sending you special messages or that the radio is broadcasting your thoughts for everyone to hear. You might also feel paranoid and believe that others are trying to harm you.

Thought disorders. You might have trouble organizing your thoughts, and you might speak in a way that's hard for others to understand. Perhaps you stop talking in the middle of a thought because you feel like it's been taken out of your head. This is called thought withdrawal. Another type of disordered thinking, called thought blocking, happens when someone has a sudden stopping of their flow of thinking, and as a consequence, they may become silent until a new thought enters their mind.

Movement disorders. You might move your body over and over again as if you're upset, or you might stop moving and responding. Doctors call this catatonia.

Negative symptoms. Maybe you speak in a dull, flat tone; have trouble following through; lack interest in your daily life; and find it hard to keep up relationships. You might appear to be depressed. But while sadness, tearfulness, and other symptoms point to depression, so-called negative symptoms more likely point to a problem with the way the brain works.

Read more about the symptoms of schizophrenia.

In general, schizophrenia onset before age 18 is considered early-onset and before age 13 may be called childhood or very early-onset schizophrenia. However, different doctors and scholars may use different terms and age ranges.

Schizophrenia is extremely rare in very young children, but it can happen. Signs include:

  • Talking delays
  • Late crawling or walking
  • Lack of eye contact
  • Movements like arm flapping or rocking
  • Trouble controlling emotions and impulses
  • Attention issues
  • Problems telling the difference between dreams or make-believe and reality
  • Trouble managing daily tasks like bathing and brushing teeth

Parents of teens might notice:

  • Not spending as much time with friends and family
  • Drop in school performance
  • Trouble sleeping
  • Bad mood
  • Depression
  • No motivation
  • Using drugs or alcohol
  • Uncharacteristic behavior

Teens are less likely to have delusions but more likely to have visual hallucinations.

Find out more on early childhood schizophrenia symptoms.

It's less common, but sometimes, schizophrenia onset can take place later in life. Experts consider late-onset schizophrenia to mean a diagnosis between the ages of 40 and 60, while a diagnosis beyond age 60 is considered very late-onset schizophrenia-like psychosis.

People with late-onset schizophrenia are more likely to have symptoms like delusions and hallucinations. They're less likely to have negative symptoms, disorganized thoughts, impaired learning, or trouble understanding information.

Doctors think genetics may be to blame, just as it is with early-onset schizophrenia. They also think late-onset might be a subtype that doesn't affect the person until the right trigger appears. People with cognitive, vision, or hearing problems or those who are suspicious, isolated, or reclusive may be more likely to get it.

Schizophrenia onset most often takes place between your late teens and early 30s. People assigned male at birth are usually diagnosed in their late teens to early 20s, while people assigned female at birth tend to get diagnosed in their late 20s to early 30s. It's rare to develop this mental health condition before age 12 or after age 40. Brain changes during adolescence may explain why symptoms usually appear at that age.