OREGON GRAPE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Oregon grape (Mahonia aquifolium) is a plant native to the western coast of North America. It has a history of use in American folk medicine.

Oregon grape contains chemicals that might help fight bacterial and fungal infections. Oregon grape might also reduce inflammation from skin conditions such as psoriasis.

People use Oregon grape for scaly, itchy skin (psoriasis). It is also used for eczema, indigestion, and many other conditions, but there is no good scientific evidence to support these uses.

Oregon grape is sometimes called Oregon barberry. Don't confuse Oregon grape with European barberry. These are not the same.

Uses & Effectiveness

Possibly Effective for

Scaly, itchy skin (psoriasis). Applying a specific Oregon grape extract cream (Relieva, Apollo Pharmaceutical) to the skin somewhat improves symptoms and quality of life in people with psoriasis.

There is interest in using Oregon grape for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Oregon grape is commonly consumed in foods. But there isn't enough reliable information to know if Oregon grape is safe to use in larger amounts as medicine or what the side effects might be.

When applied to the skin: Oregon grape is possibly safe when a specific 10% Oregon grape cream (Relieva, Apollo Pharmaceutical) is used for up to 12 weeks. Side effects might include itching, burning, irritation, and allergic reactions.

Special Precautions and Warnings

Pregnancy: Oregon grape Is likely unsafe when taken by mouth during pregnancy. Oregon grape contains a chemical called berberine, which might cause harm to the fetus.

Breast-feeding: Oregon grape is likely unsafe when taken by mouth while breast-feeding. Oregon grape contains a chemical called berberine, which can be transferred to the infant through breast milk.

Children: Oregon grape is likely unsafe when given to infants by mouth. The berberine in Oregon grape can cause brain damage in newborns, particularly premature newborns who have jaundice. There isn't enough reliable information to know if Oregon grape is safe when used by older children.

Interactions

Moderate Interaction

Be cautious with this combination

Cyclosporine (Neoral, Sandimmune) interacts with OREGON GRAPE
The body breaks down cyclosporine to get rid of it. Oregon grape might decrease how fast the body breaks down cyclosporine. This might cause there to be too much cyclosporine in the body and potentially cause side effects.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with OREGON GRAPE
Some medications are changed and broken down by the liver. Oregon grape might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with OREGON GRAPE
Some medications are changed and broken down by the liver. Oregon grape might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with OREGON GRAPE
Some medications are changed and broken down by the liver. Oregon grape might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications for diabetes (Antidiabetes drugs) interacts with OREGON GRAPE
Oregon grape might lower blood sugar levels. Taking Oregon grape along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure (Antihypertensive drugs) interacts with OREGON GRAPE
Oregon grape might lower blood pressure. Taking Oregon grape along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with OREGON GRAPE
Oregon grape might slow blood clotting. Taking Oregon grape along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Sedative medications (CNS depressants) interacts with OREGON GRAPE
Oregon grape might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking Oregon grape with sedative medications might cause breathing problems and/or too much sleepiness.
Medications moved by pumps in cells (P-glycoprotein substrates) interacts with OREGON GRAPE
Some medications are moved in and out of cells by pumps. Oregon grape might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Dosing

Oregon grape has most often been applied to the skin as a topical cream in adults. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

REFERENCES:

Marotta, F., Weksler, M., Naito, Y., Yoshida, C., Yoshioka, M., and Marandola, P. Nutraceutical supplementation: effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype: a randomized, placebo-controlled, cross-over study. Ann.N.Y.Acad.Sci 2006;1067:400-407. View abstract.

Marotta, F., Yoshida, C., Barreto, R., Naito, Y., and Packer, L. Oxidative-inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation. J Gastroenterol.Hepatol. 2007;22(5):697-703. View abstract.

Matinian, L. A., Nagapetian, KhO, Amirian, S. S., Mkrtchian, S. R., Mirzoian, V. S., and Voskanian, R. M. [Papain phonophoresis in the treatment of suppurative wounds and inflammatory processes]. Khirurgiia (Mosk) 1990;(9):74-76. View abstract.

Menon, V., Ram, M., Dorn, J., Armstrong, D., Muti, P., Freudenheim, J. L., Browne, R., Schunemann, H., and Trevisan, M. Oxidative stress and glucose levels in a population-based sample. Diabet.Med 2004;21(12):1346-1352. View abstract.

Miyoshi, N., Uchida, K., Osawa, T., and Nakamura, Y. Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells. Int J Cancer 2-1-2007;120(3):484-492. View abstract.

Mojica-Henshaw, M. P., Francisco, A. D., De, Guzman F., and Tigno, X. T. Possible immunomodulatory actions of Carica papaya seed extract. Clin Hemorheol.Microcirc. 2003;29(3-4):219-229. View abstract.

Mourvaki, E., Gizzi, S., Rossi, R., and Rufini, S. Passionflower fruit-a "new" source of lycopene? J Med Food 2005;8(1):104-106. View abstract.

Nakamura, Y. and Miyoshi, N. Cell death induction by isothiocyanates and their underlying molecular mechanisms. Biofactors 2006;26(2):123-134. View abstract.

Odani, S., Yokokawa, Y., Takeda, H., Abe, S., and Odani, S. The primary structure and characterization of carbohydrate chains of the extracellular glycoprotein proteinase inhibitor from latex of Carica papaya. Eur.J Biochem. 10-1-1996;241(1):77-82. View abstract.

Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. View abstract.

Osato, J. A., Korkina, L. G., Santiago, L. A., and Afanas'ev, I. B. Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. Nutrition 1995;11(5 Suppl):568-572. View abstract.

Otsuki, N., Dang, N. H., Kumagai, E., Kondo, A., Iwata, S., and Morimoto, C. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2-17-2010;127(3):760-767. View abstract.

Owoyele, B. V., Adebukola, O. M., Funmilayo, A. A., and Soladoye, A. O. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008;16(4):168-173. View abstract.

Pieper, B. and Caliri, M. H. Nontraditional wound care: A review of the evidence for the use of sugar, papaya/papain, and fatty acids. J.Wound.Ostomy.Continence.Nurs. 2003;30(4):175-183. View abstract.

Potischman, N. and Brinton, L. A. Nutrition and cervical neoplasia. Cancer Causes Control 1996;7(1):113-126. View abstract.

Rakhimov, M. R. [Pharmacological study of papain from the papaya plant cultivated in Uzbekistan]. Eksp.Klin.Farmakol. 2000;63(3):55-57. View abstract.

Rimbach, G., Guo, Q., Akiyama, T., Matsugo, S., Moini, H., Virgili, F., and Packer, L. Ferric nitrilotriacetate induced DNA and protein damage: inhibitory effect of a fermented papaya preparation. Anticancer Res 2000;20(5A):2907-2914. View abstract.

Roychowdhury, T., Uchino, T., Tokunaga, H., and Ando, M. Survey of arsenic in food composites from an arsenic-affected area of West Bengal, India. Food Chem Toxicol 2002;40(11):1611-1621. View abstract.

Salleh, M. N., Runnie, I., Roach, P. D., Mohamed, S., and Abeywardena, M. Y. Inhibition of low-density lipoprotein oxidation and up-regulation of low-density lipoprotein receptor in HepG2 cells by tropical plant extracts. J Agric.Food Chem. 6-19-2002;50(13):3693-3697. View abstract.

Starley, I. F., Mohammed, P., Schneider, G., and Bickler, S. W. The treatment of paediatric burns using topical papaya. Burns 1999;25(7):636-639. View abstract.

Vallis, C. P. and Lund, M. H. Effect of treatment with Carica papaya on resolution of edema and ecchymosis following rhinoplasty. Curr.Ther.Res.Clin.Exp. 1969;11(6):356-359. View abstract.

Rohrer, U., Kunz, E. M., Lenkeit, K., Schaffner, W., and Meyer, J. Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. Schweiz.Monatsschr.Zahnmed. 2007;117(11):1126-1131. View abstract.

Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes 2014;7:241-53. View abstract.

Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 1969;15:1067-76. View abstract.

Ang ES, Lee ST, Gan CS, et al. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. MedGenMed 2001;3:3. View abstract.

Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice. J Pharm Pharmacol 2001;53:763-8. . View abstract.

Bernstein S, Donsky H, Gullver W, et al. Treatment of mild to moderate psoriasis with Relieva, a Mahonia aquifolium extract - a double blind, placebo-controlled study. Am J Ther 2006;13:121-6. View abstract.

Bhide MB, Chavan SR, Dutta NK. Absorption, distribution and excretion of berberine. Indian J Med Res 1969;57:2128-31. View abstract.

Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. View abstract.

Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. View abstract.

Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. View abstract.

Fan Y, Zhou Z, Zhang L. Effect of Oregon grape root extracts on P-glycoprotein mediated transport in in vitro cell lines. J Pharm Pharm Sci 2024;26:11927. View abstract.

Fukuda K, Hibiya Y, Mutoh M, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66:227-33. View abstract.

Gieler U, von der Weth A, Heger M. Mahonia aquifolium- a new type of topical treatment for psoriasis. J Dermatol Treatment 1995;6:31-4.

Gulliver WP, Donsky HJ. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther 2005;12:398-406. View abstract.

Gupte S. Use of berberine in treatment of giardiasis. Am J Dis Child 1975;129:866. View abstract.

Hsiang CY, Wu SL, Cheng SE, Ho TY. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 2005;12:791-801. View abstract.

Hyodo T, Taira T, Kumakura M, et al. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Nephron 2002;90:240. View abstract.

Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. View abstract.

Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25. View abstract.

Kim SH, Shin DS, Oh MN, et al. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4.. View abstract.

Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. View abstract.

Li B, Shang JC, Zhou QX. [Study of total alkaloids from rhizoma coptis chinensis on experimental gastric ulcers]. Chin J Integr Med 2005;11:217-21. View abstract.

Natural Health Remedies. Health Canada. Available at: www.hc-sc.gc.ca/english/archives/96-97/herbnae.html (Accessed 16 July 1999).

Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect Dis 1987;155:979-84. View abstract.

Rackova L, Majekova M, Kost'alova D, Stefek M. Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. Bioorg Med Chem 2004;12:4709-15. View abstract.

Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol Lett 1999;68:391-5. View abstract.

Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med 2001;67:561-4. View abstract.

Slobodnikova L, Kost'alova D, Labudova D, et al. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytother Res 2004;18:674-6. View abstract.

Sun D, Courtney HS, Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrob Agents Chemother 1988;32:1370-4. View abstract.

Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos 2004;32:405-12. . View abstract.

Vollekova A, Kost'alova D, Kettmann V, Toth J. Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytother Res 2003;17:834-7. View abstract.

Wiesenauer M, Lydtke R. Mahonia aquifolium in patients with Psoriasis vulgaris; an intraindividual study. Phytomedicine 1996;3:231-5.

Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. View abstract.

Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-6. View abstract.

Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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OREGON GRAPE - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Possibly Effective for

Side Effects

Special Precautions and Warnings

Interactions

Moderate Interaction

Cyclosporine (Neoral, Sandimmune) interacts with OREGON GRAPE

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with OREGON GRAPE

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with OREGON GRAPE

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with OREGON GRAPE

Medications for diabetes (Antidiabetes drugs) interacts with OREGON GRAPE

Medications for high blood pressure (Antihypertensive drugs) interacts with OREGON GRAPE

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with OREGON GRAPE

Sedative medications (CNS depressants) interacts with OREGON GRAPE

Medications moved by pumps in cells (P-glycoprotein substrates) interacts with OREGON GRAPE

Dosing

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