Krieger, J. W., Crowe, M., and Blank, S. E. Chronic glutamine supplementation increases nasal but not salivary IgA during 9 days of interval training. J.Appl.Physiol 2004;97(2):585-591. View abstract.
Krzywkowski, K., Petersen, E. W., Ostrowski, K., Kristensen, J. H., Boza, J., and Pedersen, B. K. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am.J.Physiol Cell Physiol 2001;281(4):C1259-C1265. View abstract.
Lacey, J. M., Crouch, J. B., Benfell, K., Ringer, S. A., Wilmore, C. K., Maguire, D., and Wilmore, D. W. The effects of glutamine-supplemented parenteral nutrition in premature infants. JPEN J.Parenter.Enteral Nutr. 1996;20(1):74-80. View abstract.
Lehmkuhl, M., Malone, M., Justice, B., Trone, G., Pistilli, E., Vinci, D., Haff, E. E., Kilgore, J. L., and Haff, G. G. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures. J Strength.Cond.Res 2003;17(3):425-438. View abstract.
Lima, A. A., Brito, L. F., Ribeiro, H. B., Martins, M. C., Lustosa, A. P., Rocha, E. M., Lima, N. L., Monte, C. M., and Guerrant, R. L. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr.Gastroenterol.Nutr. 2005;40(1):28-35. View abstract.
Lin, M. T., Kung, S. P., Yeh, S. L., Liaw, K. Y., Wang, M. Y., Kuo, M. L., Lee, P. H., and Chen, W. J. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J Gastroenterol. 10-21-2005;11(39):6197-6201. View abstract.
Lin, M. T., Kung, S. P., Yeh, S. L., Lin, C., Lin, T. H., Chen, K. H., Liaw, K. Y., Lee, P. H., Chang, K. J., and Chen, W. J. The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients. Clin.Nutr. 2002;21(3):213-218. View abstract.
M'bemba, J., Cynober, L., de, Bandt P., Taverna, M., Chevalier, A., Bardin, C., Slama, G., and Selam, J. L. Effects of dipeptide administration on hypoglycaemic counterregulation in type 1 diabetes. Diabetes Metab 2003;29(4 Pt 1):412-417. View abstract.
MacBurney, M., Young, L. S., Ziegler, T. R., and Wilmore, D. W. A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplant patients. J.Am.Diet.Assoc. 1994;94(11):1263-1266. View abstract.
May, P. E., Barber, A., D'Olimpio, J. T., Hourihane, A., and Abumrad, N. N. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am.J.Surg. 2002;183(4):471-479. View abstract.
Mok, E., Eleouet-Da, Violante C., Daubrosse, C., Gottrand, F., Rigal, O., Fontan, J. E., Cuisset, J. M., Guilhot, J., and Hankard, R. Oral glutamine and amino acid supplementation inhibit whole-body protein degradation in children with Duchenne muscular dystrophy. Am.J Clin.Nutr. 2006;83(4):823-828. View abstract.
Morais, A. A., Santos, J. E., and Faintuch, J. [Comparative study of arginine and glutamine supplements in malnourished surgical patients]. Rev.Hosp.Clin.Fac.Med.Sao Paulo 1995;50(5):276-279. View abstract.
Morlion, B. J., Siedhoff, H. P., Joosten, U., Koller, M., Konig, W., Furst, P., and Puchstein, C. [Immunomodulation after parenteral glutamine administration in colorectal surgery]. Langenbecks Arch.Chir Suppl Kongressbd. 1996;113:342-344. View abstract.
Neri, A., Mariani, F., Piccolomini, A., Testa, M., Vuolo, G., and Di Cosmo, L. Glutamine-supplemented total parenteral nutrition in major abdominal surgery. Nutrition 2001;17(11-12):968-969. View abstract.
Neu, J., Roig, J. C., Meetze, W. H., Veerman, M., Carter, C., Millsaps, M., Bowling, D., Dallas, M. J., Sleasman, J., Knight, T., and Auestad, N. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J.Pediatr. 1997;131(5):691-699. View abstract.
O'Riordain, M. G., De Beaux, A., and Fearon, K. C. Effect of glutamine on immune function in the surgical patient. Nutrition 1996;12(11-12 Suppl):S82-S84. View abstract.
O'Riordain, M. G., Fearon, K. C., Ross, J. A., Rogers, P., Falconer, J. S., Bartolo, D. C., Garden, O. J., and Carter, D. C. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann.Surg. 1994;220(2):212-221. View abstract.
Ockenga, J., Borchert, K., Rifai, K., Manns, M. P., and Bischoff, S. C. Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin.Nutr. 2002;21(5):409-416. View abstract.
Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Clinical and protein metabolic efficacy of glutamine granules-supplemented enteral nutrition in severely burned patients. Burns 2005;31(3):342-346. View abstract.
Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 2004;30(2):135-139. View abstract.
Peng, X., You, Z. Y., Huang, X. K., Zhang, S. Q., He, G. Z., Xie, W. G., and Quan, Z. F. [Effects of glutamine granules on protein metabolism in trauma patients]. Zhonghua Wai Ke.Za Zhi. 4-7-2004;42(7):406-409. View abstract.
Pertkiewicz, M., Slotwinski, R., Majewska, K., and Szczygiel, B. [Clinical evaluation of amino acid solution]. Pol.Merkur Lekarski. 1999;7(41):211-214. View abstract.
Petersson, B., von der, Decken A., Vinnars, E., and Wernerman, J. Long-term effects of postoperative total parenteral nutrition supplemented with glycylglutamine on subjective fatigue and muscle protein synthesis. Br.J Surg. 1994;81(10):1520-1523. View abstract.
Piccirillo, N., De Matteis, S., Laurenti, L., Chiusolo, P., Sora, F., Pittiruti, M., Rutella, S., Cicconi, S., Fiorini, A., D'Onofrio, G., Leone, G., and Sica, S. Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 2003;88(2):192-200. View abstract.
Poindexter, B. B., Ehrenkranz, R. A., Stoll, B. J., Wright, L. L., Poole, W. K., Oh, W., Bauer, C. R., Papile, L. A., Tyson, J. E., Carlo, W. A., Laptook, A. R., Narendran, V., Stevenson, D. K., Fanaroff, A. A., Korones, S. B., Shankaran, S., Finer, N. N., and Lemons, J. A. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004;113(5):1209-1215. View abstract.
Powell-Tuck, J. Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery. Gut 1999;44(2):155. View abstract.
Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. View abstract.
Ito, C., Yamaguchi, K., Shibutani, Y., Suzuki, K., Yamazaki, Y., Komachi, H., Ohnishi, H., and Fujimura, H. [Anti-inflammatory actions of proteases, bromelain, trypsin and their mixed preparation (author's transl)]. Nippon Yakurigaku Zasshi 4-20-1979;75(3):227-237. View abstract.
Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30. View abstract.
Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial. Radiother.Oncol. 2002;65(1):17-22. View abstract.
Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. View abstract.
Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-5. View abstract.
Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. View abstract.
Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. View abstract.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Cediel G, Olivares M, Gaitán D, Flores S, Brito A, Pizarro F. Effect of trypsin and mucin on heme iron bioavailability in humans. Biol Trace Elem Res. 2012;150(1-3):37-41. View abstract.
Comparison of Chronic Wound Care Products. Pharmacist's Letter/Prescriber's Letter 2008;12(3):1203.
Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. View abstract.
Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47 Suppl:S23-8. View abstract.
Hellgren L, Vincent J. Degradation and liquefication effect of streptokinase-streptodornase and stabilised trypsin on tissue necroses, crusts of fibrinoid, purulent exudate and clotted blood from leg ulcers. J Int Med Res 1977;5:334-7. View abstract.
Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. View abstract.
Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. View abstract.
Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest 2000;19:15-23.
Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. View abstract.
Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. View abstract.
Popiela T, Kulig J, Klek S, Wachol D, Bock PR, Hanisch J. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek. 2000;57 Suppl 5:142. View abstract.
RaviKumar T, Ramakrishnan M, Jayaraman V, Babu M. Effect of trypsin-chymotrypsin (Chymoral Forte D.S.) preparation on the modulation of cytokine levels in burn patients. Burns. 2001;27(7):709-16. View abstract.
Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac Surg. 2013;71(7):1261-7. View abstract.
Spraycar M, ed. Stedman's Medical Dictionary. 26th ed. Baltimore, MD: Williams & Wilkins, 1995.
Suomalainen O. Evaluation of two enzyme preparations-Trypure and Varidase in traumatic ulcers. Ann Chir Gynaecol 1983;72:62-5. View abstract.
Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial. J Assoc Physicians India. 2001;49:617-21. View abstract.
US Department of Justice. U.S. Files Complaint Against Texas-Based Healthpoint Ltd. Under the False Claims Act. https://www.justice.gov/opa/pr/us-files-complaint-against-texas-based-healthpoint-ltd-under-false-claims-act. (Accessed June 19, 2019).
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